Mouse Anti-GAP43 Recombinant Antibody (VS3-CJ721)
CAT#: VS3-CJ721
This product is a mouse antibody that recognizes human, mouse, and rat GAP43.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line SH-SY5Y
Immunofluorescent staining of human cell line SH-SY5Y shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13392/1510_B4_2_selected.jpg
Normal Tissue
Figure 2 Colon
Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15600/35117_A_8_3.jpg
Normal Tissue
Figure 3 High expression in cerebral cortex
Endothelial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear Glial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15600/35117_B_9_5.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (AF22, NTERA-2, SCLC-21H, SH-SY5Y, U-87 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000172020-GAP43
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Specifications
- Immunogen
- Recombinant protein corresponding to human GAP43
- Host Species
- Mouse
- Type
- Mouse IgG1, κ
- Specificity
- Human, Mouse, Rat GAP43
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, IHC
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity Purified
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 30% Glycerol, 0.87% NaCl, 0.42% Potassium phosphate, pH7.3.
- Preservative
- 0.01% Sodium Azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipped at 4°C
Applications
- Application Notes
- This antibody has been tested for use in Western Blot (1:1000-1:2000), Immunohistochemistry (1:200-1:500).
Target
- Alternative Names
- B-50; PP46; GAP-43
- Gene ID
- 2596
- UniProt ID
- P17677
- Sequence Similarities
- Belongs to the neuromodulin family.
- Cellular Localization
- Cell membrane, Cell projection, Cytoplasm, Membrane, Synapse
- Post Translation Modifications
- Phosphorylated (By similarity).
Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity (By similarity).
Palmitoylated by ZDHHC3 (By similarity).
Palmitoylation is regulated by ARF6 and is essential for plasma membrane association and axonal and dendritic filopodia induction (PubMed:14978216).
Deacylated by LYPLA2 (PubMed:21152083).
- Protein Refseq
- NP_001123536.1; NP_002036.1
- Function
- This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
See other products for "GAP43"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1629z | Mouse Anti-GAP43 Recombinant Antibody (clone 29G1) | WB, ICC, IF, IHC | Mouse IgG1 |
| MOB-2432CT | Recombinant Mouse anti-Chicken GAP43 Monoclonal antibody (ZF370) | WB, ELISA, IHC-P, IHC-Fr | |
| ZG-0052C | Mouse Anti-GAP43 Antibody (clone Mix) | WB, IHC-P, IF | Mouse IgG |
| VS3-WK1840 | Recombinant Rabbit Anti-GAP43 Capture Antibody (clone R39-2C-4) | ELISA | Rabbit IgG |
| VS3-WK1841 | Recombinant Rabbit Anti-GAP43 Detection Antibody (clone R81-6N-1) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0698MZ | Chicken Anti-Gap43 Polyclonal IgY | ICC, IF, IHC, WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1397 | Hi-Affi™ Rabbit Anti-GAP43 Recombinant Antibody (clone DS1397AB) | WB, IP, ICC, FC, IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC684 | AbPlus™ Anti-GAP43 Magnetic Beads (VS-0724-YC684) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2725 | Anti-GAP43 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2726 | Anti-Mouse GAP43 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2727 | Anti-Rat GAP43 Immunohistochemistry Kit | IHC |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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