Anti-GAS1 (clone W24V100) Recombinant Antibody Coupled Liposome (VS-1024-FY102)
CAT#: VS-1024-FY102
The anti-GAS1 antibody can bind to liposomes, endowing them with the ability to target glioma cells. This characteristic offers broad prospects for its clinical application. Based on the binding technology of the anti-GAS1 antibody and liposomes, it may provide a new and effective treatment option for glioma patients in future clinical applications, advancing the development of anti-tumor therapies.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEK 293
Immunofluorescent staining of human cell line HEK 293 shows localization to nuclear speckles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/36085/765_G1_1_selected.jpg
Normal Tissue
Figure 2 IHC staining of human pancreas
Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/66902/155616_A_2_3_selected.jpg
Normal Tissue
Figure 3 Lymph node
Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/66902/155616_A_7_8.jpg
Normal Tissue
Figure 4 Cerebral cortex
Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/66902/155616_B_7_5.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/66902/155616_A_8_5.jpg
Normal Tissue
Figure 6 Urinary bladder
Urothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/66902/155616_A_6_5.jpg
Normal Tissue
Figure 7 Testis
Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/66902/155616_A_6_6.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (AN3-CA, ASC diff, BJ hTERT+, HSkMC, RH-30)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000180447-GAS1
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More Infomation
Specifications
- Potential Clinical Applications
- Glioma
Product Composition
- Clone
- W24V100
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant mouse monoclonal antibody that was designed to specifically bind to human Growth Arrest Specific 1 (GAS1). GAS1 is a protein that plays a crucial role in regulating cell growth and development. By targeting GAS1, this monoclonal antibody can potentially modulate the signaling pathways associated with cell proliferation and differentiation.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- GAS1
- Introduction
- Growth arrest-specific 1 plays a role in growth suppression. GAS1 blocks entry to S phase and prevents cycling of normal and transformed cells. Gas1 is a putative tumor suppressor gene.
- Alternative Names
- GAS1; Growth arrest-specific protein 1 precursor
- Full Name
- Growth Arrest Specific 1
- Gene ID
- 2619
- UniProt ID
- P54826
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn117 ( NX_P54826 [NX_P54826-1] )
Ubiquitination at Lys192 ( NX_P54826 [NX_P54826-1] )
Modification sites at PhosphoSitePlus ( P54826 )
Glycosylation from GlyGen (P54826) 1 site, 1 N-linked glycan (1 site)
- Protein Refseq
- NP_002039.2
- Function
- Specific growth arrest protein involved in growth suppression.
Blocks entry to S phase.
Prevents cycling of normal and transformed cells.
Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity).
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "GAS1"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC4440 | PE-A*01:01/Human GAS1 (GSDGGLDDY) MHC Tetramer | FCM | |
| MHC-LC4441 | PE-A*69:01/Human GAS1 (GSDGGLDDY) MHC Tetramer | FCM |
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