Mouse Anti-Glycoprotein Recombinant Antibody (clone 6D6)
CAT#: VS-0724-YC47
6D6 is a cross-reactive GP-specific mAb. This mab recognizes the putative epitope in the highly conserved IFL and neutralizes infectivity of representative isolates of all known ebolavirus species by inhibiting the membrane fusion. MAb 6D6 was found to be GP-specific and to efficiently neutralize the infectivity of vesicular stomatitis virus (VSV) pseudotyped with GPs of all known ebolaviruses (EBOV, SUDV, TAFV, BDBV, and RESTV), including the variant that caused the latest outbreak in West Africa (EBOV2014), but not Marburg virus (MARV), a related filovirus that causes human disease similar to EVD.
Specifications
- Immunogen
- EBOV VLPs
- Host Species
- Mouse
- Derivation
- Hybridoma
- Type
- Mouse IgG1
- Specificity
- glycoprotein (GP)
- Species Reactivity
- EBOV, SUDV, TAFV, BDBV, RESTV
- Clone
- 6D6
- Applications
- ELISA, Neut, FuncS
Product Property
- Purification
- Protein G purified
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The 50% inhibitory concentrations (IC₅₀) of 6D6 for VSVs bearing EBOV1976, EBOV2014, SUDV, TAFV, BDBV, and RESTV GPs were 0.05, 0.12, 0.19, 0.33, 0.24, and 0.62 μg/ml, respectively.
Target
- Alternative Names
- EBOV glycoprotein (GP); glycoprotein; GP
- Long Name
- Ebola virus (EBOV) surface glycoprotein (GP)
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
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- Product Name
Secondary Antibody
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-163 | Recombinant Mouse Anti-Glycoprotein Antibody (523-11) | WB, ELISA, Neut, FuncS | IgG |
| PABX-163-F (E) | Recombinant Mouse Anti-Glycoprotein Antibody Fab Fragment (523-11) | WB, ELISA, Neut, FuncS | Fab |
| CAT | Product Name | Application | Type |
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| PABX-163-S (P) | Recombinant Mouse Anti-Glycoprotein Antibody scFv Fragment (523-11) | WB, ELISA, Neut, FuncS | scFv |
| CAT | Product Name | Application | Type |
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| HPAB-0714LY-S(P) | Humanized Anti-Glycoprotein Antibody scFv Fragment (Ab-1) | ELISA, FC | |
| HPAB-0715LY-S(P) | Humanized Anti-Glycoprotein Antibody scFv Fragment (Ab-2) | ELISA, FC | |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0714LY | Recombinant Humanized Anti-Glycoprotein Antibody (Ab-1) | ELISA, FC | |
| HPAB-0715LY | Recombinant Humanized Anti-Glycoprotein Antibody (Ab-2) | ELISA, FC | |
| HPAB-0716LY | Recombinant Humanized Anti-Glycoprotein Antibody (Ab-3) | ELISA, FC | |
| HPAB-0717LY | Recombinant Humanized Anti-Glycoprotein Antibody (Ab-4) | ELISA, FC | |
| HPAB-0718LY | Recombinant Humanized Anti-Glycoprotein Antibody (Ab-5) | ELISA, FC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0714LY-F(E) | Humanized Anti-Glycoprotein Antibody Fab Fragment (Ab-1) | ELISA, FC | |
| HPAB-0715LY-F(E) | Humanized Anti-Glycoprotein Antibody Fab Fragment (Ab-2) | ELISA, FC | |
| HPAB-0716LY-F(E) | Humanized Anti-Glycoprotein Antibody Fab Fragment (Ab-3) | ELISA, FC | |
| HPAB-0717LY-F(E) | Humanized Anti-Glycoprotein Antibody Fab Fragment (Ab-4) | ELISA, FC | |
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