Mouse Anti-Glycoprotein Recombinant Antibody (clone 6D6) (CAT#: VS-0724-YC47)
6D6 is a cross-reactive GP-specific mAb. This mab recognizes the putative epitope in the highly conserved IFL and neutralizes infectivity of representative isolates of all known ebolavirus species by inhibiting the membrane fusion. MAb 6D6 was found to be GP-specific and to efficiently neutralize the infectivity of vesicular stomatitis virus (VSV) pseudotyped with GPs of all known ebolaviruses (EBOV, SUDV, TAFV, BDBV, and RESTV), including the variant that caused the latest outbreak in West Africa (EBOV2014), but not Marburg virus (MARV), a related filovirus that causes human disease similar to EVD.
Specific Inquiry
Specifications
- Immunogen
- EBOV VLPs
- Host Species
- Mouse
- Derivation
- Hybridoma
- Type
- Mouse IgG1
- Specificity
- glycoprotein (GP)
- Species Reactivity
- EBOV, SUDV, TAFV, BDBV, RESTV
- Clone
- 6D6
- Applications
- ELISA, Neut, FuncS
Product Property
- Purification
- Protein G purified
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The 50% inhibitory concentrations (IC₅₀) of 6D6 for VSVs bearing EBOV1976, EBOV2014, SUDV, TAFV, BDBV, and RESTV GPs were 0.05, 0.12, 0.19, 0.33, 0.24, and 0.62 μg/ml, respectively.
Target
- Alternative Names
- EBOV glycoprotein (GP); glycoprotein; GP
- Long Name
- Ebola virus (EBOV) surface glycoprotein (GP)
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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MHC Tetramer Products for Virology
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-163 | Recombinant Mouse Anti-Glycoprotein Antibody (523-11) | WB, ELISA, Neut, FuncS | IgG |
| PABX-163-F (E) | Recombinant Mouse Anti-Glycoprotein Antibody Fab Fragment (523-11) | WB, ELISA, Neut, FuncS | Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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