Recombinant Mouse Anti-Glycoprotein Antibody (523-11) (CAT#: PABX-163)
Anti-Glycoprotein antibody is a Mouse antibody of IgG class that binds to an Glycoprotein.
Specific Inquiry
ELISA
Figure 1 ELISA-binding profiles.
Mean values were determined from three independent experiments and are presented with SD values indicated by error bars.
Yang, F., Lin, S., Ye, F., Yang, J., Qi, J., Chen, Z., ... & Lu, G. (2020). Structural analysis of rabies virus glycoprotein reveals pH-dependent conformational changes and interactions with a neutralizing antibody. Cell host & microbe, 27(3), 441-453.
Block
Figure 2 Blockage of the glycoprotein-mediated cell-cell fusion by 523-11.
Syncytia formed are marked with arrows. Scale bar: 200 μm.
Yang, F., Lin, S., Ye, F., Yang, J., Qi, J., Chen, Z., ... & Lu, G. (2020). Structural analysis of rabies virus glycoprotein reveals pH-dependent conformational changes and interactions with a neutralizing antibody. Cell host & microbe, 27(3), 441-453.
Inhib
Figure 3 Inhibition of RABV infection by 523-11.
BHK-21 cells are left uninfected (Blank) or infected with the Flury strain of RABV in the absence (RABV) or presence of the indicated antibodies (RABV + Iso-control and RABV + 523-11) and stained with a FITC-labeled RABV N-protein antibody (green) and Evans blue (light red). Representative cell images are shown. Scale bar: 200 μm.
Yang, F., Lin, S., Ye, F., Yang, J., Qi, J., Chen, Z., ... & Lu, G. (2020). Structural analysis of rabies virus glycoprotein reveals pH-dependent conformational changes and interactions with a neutralizing antibody. Cell host & microbe, 27(3), 441-453.
WB
Figure 4 A western blot assay characterizing the interactions of the indicated antibodies with denatured RABV-G-ΔFuLp.
Yang, F., Lin, S., Ye, F., Yang, J., Qi, J., Chen, Z., ... & Lu, G. (2020). Structural analysis of rabies virus glycoprotein reveals pH-dependent conformational changes and interactions with a neutralizing antibody. Cell host & microbe, 27(3), 441-453.
SPR
Figure 5 Characterization of the antigen/antibody interaction by surface plasmon resonance.
The binding profiles are shown. The marked χ2/RUmax value (< 10%) highlights the goodness of fit between the experimental data and the model algorithm. Characterization of the interaction at pH 8.0.
Yang, F., Lin, S., Ye, F., Yang, J., Qi, J., Chen, Z., ... & Lu, G. (2020). Structural analysis of rabies virus glycoprotein reveals pH-dependent conformational changes and interactions with a neutralizing antibody. Cell host & microbe, 27(3), 441-453.
SPR
Figure 6 Characterization of the antigen/antibody interaction by surface plasmon resonance.
The binding profiles are shown. The marked χ2/RUmax value (< 10%) highlights the goodness of fit between the experimental data and the model algorithm. Characterization of the interaction at pH 6.5.
Yang, F., Lin, S., Ye, F., Yang, J., Qi, J., Chen, Z., ... & Lu, G. (2020). Structural analysis of rabies virus glycoprotein reveals pH-dependent conformational changes and interactions with a neutralizing antibody. Cell host & microbe, 27(3), 441-453.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- IgG
- Specificity
- Tested positive against native Rabies virus Glycoprotein
- Species Reactivity
- Rabies virus
- Clone
- 523-11
- Applications
- Can be useful in applications such as: Western blot; Enzyme-linked Immunosorbent Assay; Neutralization; Functional Study
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Target
- Alternative Names
- Glycoprotein
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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MHC Tetramer Products for Virology
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-163-S (P) | Recombinant Mouse Anti-Glycoprotein Antibody scFv Fragment (523-11) | WB, ELISA, Neut, FuncS | scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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