Anti-gp120-SPP-DM1 ADC
CAT#: ADC-205LZY
This ADC product is composed of an anti-gp120 antibody conjugated via SPP linker to DM1 (anti-gp120-SPP-DM1). It has demonstrated a response in human immunodeficiency virus type 1 (HIV-1) treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
Specifications
- Antibody Overview
- Mouse Anti-gp120 IgG1
- Antibody Isotype
- IgG1
- Linker
- SPP(N-succinimidyl-4-(2-pyridyldithio)pentanoate)
- Linker Class/Description
- Class: Chemically cleavable Linker-Disulfide Linker
Description: Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.
- Drug
- DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
- Drug Class/Description
- Class: Maytansinoid
Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells
Target
- Introduction
- HIV1 is equipped with the envelope gp160 glycoprotein for interaction with Langerhans cells (LCs) and dendritic cells (DCs), the members of the innate immune system, which confront the virus at the portal of virus entry in the human body. These cells are equipped with receptors by which they bind and endocytose the virus. The gp120 glycoprotein is used for binding to CD4 receptor and CCR5 co-receptor of T helper 2 (Th2) cells, and is able to induce FcepsilonRI(+) hematopoietic cells to produce IL4, which inactivates the host adaptive immune response.
- Alternative Names
- ENV; gp160; envelope glycoprotein; Envelope surface glycoprotein gp160, precursor; hypothetical protein; Envelope surface glycoprotein gp120; Envelope transmembrane domain
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See other products for "gp120"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-062 | Recombinant Human Anti-gp120 Antibody (PGT121-GL) | WB, ELISA, FuncS | IgG |
| PABX-062-F (E) | Recombinant Human Anti-gp120 Antibody Fab Fragment (PGT121-GL) | WB, ELISA, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-062-S (P) | Recombinant Human Anti-gp120 Antibody scFv Fragment (PGT121-GL) | WB, ELISA, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-002-VHH | Recombinant Anti-HIV-1 gp120 VHH Single Domain Antibody (PABX-002-VHH) | ELISA | llama VHH |
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