Anti-gp120-SPP-DM1 ADC (CAT#: ADC-205LZY)

This ADC product is composed of an anti-gp120 antibody conjugated via SPP linker to DM1 (anti-gp120-SPP-DM1). It has demonstrated a response in human immunodeficiency virus type 1 (HIV-1) treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.


Specific Inquiry
  • Datasheet
  • MSDS
  • COA

Specifications

  • Antibody Overview
  • Mouse Anti-gp120 IgG1
  • Antibody Isotype
  • IgG1
  • Linker
  • SPP(N-succinimidyl-4-(2-pyridyldithio)pentanoate)
  • Linker Class/Description
  • Class: Chemically cleavable Linker-Disulfide Linker
    Description: Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.
  • Drug
  • DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  • Drug Class/Description
  • Class: Maytansinoid
    Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
    macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells

Target

  • Introduction
  • HIV1 is equipped with the envelope gp160 glycoprotein for interaction with Langerhans cells (LCs) and dendritic cells (DCs), the members of the innate immune system, which confront the virus at the portal of virus entry in the human body. These cells are equipped with receptors by which they bind and endocytose the virus. The gp120 glycoprotein is used for binding to CD4 receptor and CCR5 co-receptor of T helper 2 (Th2) cells, and is able to induce FcepsilonRI(+) hematopoietic cells to produce IL4, which inactivates the host adaptive immune response.
  • Alternative Names
  • ENV; gp160; envelope glycoprotein; Envelope surface glycoprotein gp160, precursor; hypothetical protein; Envelope surface glycoprotein gp120; Envelope transmembrane domain

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Human Antibody

Mouse Antibody

CAT Product Name Application Type
PABX-062-S (P) Recombinant Human Anti-gp120 Antibody scFv Fragment (PGT121-GL) WB, ELISA, FuncS scFv

Single-domain Antibody

CAT Product Name Application Type
PABX-002-VHH Recombinant Anti-HIV-1 gp120 VHH Single Domain Antibody (A12) ELISA llama VHH

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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