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gp120
Loading...Anti-gp120 Products
- Recombinant Human Anti-gp120 Antibody Fab Fragment (PGT121-GL) (PABX-062-F (E))
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- Derivation: Human
- Species Reactivity: HIV
- Type: Fab
- Application: WB, ELISA, FuncS
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- Derivation: llama
- Species Reactivity: Human immunodeficiency virus 1
- Type: llama VHH
- Application: ELISA
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- Recombinant Human Anti-gp120 Antibody scFv Fragment (PGT121-GL) (PABX-062-S (P))
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- Derivation: Human
- Species Reactivity: HIV
- Type: scFv
- Application: WB, ELISA, FuncS
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- Scaffold Name: Scorpion toxins
- Target: gp120
- Species Reactivity: HIV-1
- Derivation: Phage display
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- Scaffold Name: Z-domain of protein A
- Target: gp120
- Species Reactivity: HIV-1
- Derivation: Phage display
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- Anti-gp120-SPP-DM1 ADC (ADC-205LZY)
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- Target: gp120
- Linker: SPP(N-succinimidyl-4-(2-pyridyldithio)pentanoate)
- Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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- Anti-gp120-MCC-DM1 ADC (ADC-206LZY)
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- Target: gp120
- Linker: MCC(Maleimidomethyl cyclohexane-1-carboxylate)
- Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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- Anti-gp120-mc-vc-PABC-MMAE ADC (ADC-207LZY)
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- Target: gp120
- Linker: mc-VC-PABC(maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
- Drug: MMAE (monomethyl auristatin E)
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- Anti-gp120-mc-MMAF ADC (ADC-208LZY)
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- Target: gp120
- Linker: mc(maleimidocaproyl)
- Drug: MMAF (monomethyl auristatin F)
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For Research Use Only. Not For Clinical Use.
Envelope glycoprotein GP120 (or gp120) is a glycoprotein exposed on the surface of the HIV envelope. The 120 in its name comes from its molecular weight of 120 kDa. Gp120 is essential for virus entry into cells as it plays a vital role in attachment to specific cell surface receptors. These receptors are DC-SIGN, Heparan Sulfate Proteoglycan and a specific interaction with the CD4 receptor, particularly on helper T-cells. Binding to CD4 induces the start of a cascade of conformational changes in gp120 and gp41 that lead to the fusion of the viral membrane with the host cell membrane. Binding to CD4 is mainly electrostatic although there are van der Waals interactions and hydrogen bonds.Envelope glycoprotein GP120 (or gp120) is a glycoprotein exposed on the surface of the HIV envelope.