Rabbit Anti-GRB7 Recombinant Antibody (clone R03-7M6) (CAT#: VS3-XY3372)
It is a recombinant rabbit antibody specific for GRB7 (Growth factor receptor bound protein 7), which plays a role in the regulation of cell proliferation and cell migration. It specifically targets human, mouse and rat GRB7. This product has been tested using Western Blot and Immunohistochemistry-Paraffin. The recommended dilutions of Western Blot and Immunohistochemistry-Paraffin is 1/500-1/1000 and 1/50-1/100, respectively.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HeLa
(Immunofluorescent staining of human cell line HeLa shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73538/1348_A2_4_selected.jpg
(Immunofluorescent staining of human cell line HeLa shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73538/1348_A2_4_selected.jpg
Figure 2 IHC staining of human pancreas
(Immunohistochemical staining of human pancreas shows cytoplasmic positivity in exocrine glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5226/ihc_selected.jpg
(Immunohistochemical staining of human pancreas shows cytoplasmic positivity in exocrine glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5226/ihc_selected.jpg
Figure 3 IHC staining of human fallopian tube
(Immunohistochemical staining of human fallopian tube shows moderate cytoplasmic and membranous positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73538/155959_A_8_7_selected.jpg
(Immunohistochemical staining of human fallopian tube shows moderate cytoplasmic and membranous positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73538/155959_A_8_7_selected.jpg
Figure 4 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73538/155959_B_9_5.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73538/155959_B_9_5.jpg
Figure 5 Colon
(Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73538/155959_A_7_3.jpg
(Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73538/155959_A_7_3.jpg
Figure 6 Liver
(Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73538/155959_A_7_4.jpg
(Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73538/155959_A_7_4.jpg
Figure 7 Testis
(Sertoli cells Staining: Medium Intensity: Moderate Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73538/155959_A_6_6.jpg
(Sertoli cells Staining: Medium Intensity: Moderate Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73538/155959_A_6_6.jpg
Figure 8 RNA cell line category: Cell line enriched (OE19)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000141738-GRB7
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000141738-GRB7
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat GRB7
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R03-7M6
- Applications
- WB, IHC-P
- Related Disease
- Breast Cancer; Gastric Cancer
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
Target
- Alternative Names
- Growth factor receptor bound protein 7
- Gene ID
- 2886
- UniProt ID
- Q14451
- Long Name
- Growth factor receptor bound protein 7
- Cellular Localization
- Cytoplasm, Cell junction, focal adhesion
- Post Translation Modifications
- Modification sites at PhosphoSitePlus (Q14451)
Modification sites at neXtProt (NX_Q14451)
Glycosylation from GlyGen (Q14451) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_001025173.1; NP_001229371.2
- Function
- Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling.
Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3.
Promotes activation of HRAS.
Plays a role in signal transduction in response to EGF.
Plays a role in the regulation of cell proliferation and cell migration.
Plays a role in the assembly and stability of RNA stress granules.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Rabbit Monoclonal Antibody Products
IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1503 | Rabbit Anti-GRB7 Recombinant Antibody (clone DS1503AB) | WB, IHC-P, ICC | Rabbit IgG |
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