Rabbit Anti-GRB7 Recombinant Antibody (VS13-YC465) (CAT#: VS13-YC465)
The Rabbit Anti-GRB7 Recombinant Antibody is specific for human GRB7. GRB7, an adapter protein, links growth factor receptors to signaling pathways affecting migration and cellular interactions, with gene variants contributing to processes like cancer metastasis. The anti-GRB7 antibody can be used for Immunohistochemistry (1/100-1/200).
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HeLa
(Immunofluorescent staining of human cell line HeLa shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73538/1348_A2_4_selected.jpg
(Immunofluorescent staining of human cell line HeLa shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73538/1348_A2_4_selected.jpg
Figure 2 IHC staining of human pancreas
(Immunohistochemical staining of human pancreas shows cytoplasmic positivity in exocrine glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5226/ihc_selected.jpg
(Immunohistochemical staining of human pancreas shows cytoplasmic positivity in exocrine glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5226/ihc_selected.jpg
Figure 3 IHC staining of human fallopian tube
(Immunohistochemical staining of human fallopian tube shows moderate cytoplasmic and membranous positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73538/155959_A_8_7_selected.jpg
(Immunohistochemical staining of human fallopian tube shows moderate cytoplasmic and membranous positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73538/155959_A_8_7_selected.jpg
Figure 4 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73538/155959_B_9_5.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73538/155959_B_9_5.jpg
Figure 5 Colon
(Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73538/155959_A_7_3.jpg
(Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73538/155959_A_7_3.jpg
Figure 6 Liver
(Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73538/155959_A_7_4.jpg
(Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73538/155959_A_7_4.jpg
Figure 7 Testis
(Sertoli cells Staining: Medium Intensity: Moderate Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73538/155959_A_6_6.jpg
(Sertoli cells Staining: Medium Intensity: Moderate Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73538/155959_A_6_6.jpg
Figure 8 RNA cell line category: Cell line enriched (OE19)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000141738-GRB7
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000141738-GRB7
Specifications
- Immunogen
- Recombinant human GRB7.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human GRB7
- Species Reactivity
- Human
- Applications
- IHC-P
- Conjugate
- NONE
- Related Disease
- Breast Cancer; Gastric Cancer
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity Chromatography purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS (pH 7.2) containing 50% Glycerol and 0.5% BSA.
- Preservative
- 0.02% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Immunohistochemistry (IHC): 1/100-1/200
Target
- Alternative Names
- Growth Factor Receptor Bound Protein 7; Growth Factor Receptor-Bound Protein 7; Epidermal Growth Factor Receptor GRB-7; GRB7 Adapter Protein; B47;
- Gene ID
- 2886
- UniProt ID
- Q14451
- Long Name
- Growth Factor Receptor Bound Protein 7
- Cellular Localization
- Cytoplasm; Cell junction; focal adhesion
- Protein Refseq
- NP_001025173.1; NP_001229371.2
- Function
- Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling.
Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3.
Promotes activation of HRAS.
Plays a role in signal transduction in response to EGF.
Plays a role in the regulation of cell proliferation and cell migration.
Plays a role in the assembly and stability of RNA stress granules.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Rabbit Monoclonal Antibody Products
IgG Antibody Products
IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1503 | Rabbit Anti-GRB7 Recombinant Antibody (clone DS1503AB) | WB, IHC-P, ICC | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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