AibGenesis™ Rabbit Anti-GRIA4 Recombinant Antibody (AibG-Rb-GR450)
CAT#: VS-0426-FY450
Engineered through our AI-powered antibody discovery platform, this Rabbit IgG targets GRIA4 (GluA4). Validated for WB and FC in multiple species, it provides high sensitivity for researchers investigating the developmental expression of glutamate receptors and their contribution to fast synaptic transmission in neurons.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (AF22, NTERA-2, RPMI-8226, SCLC-21H)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000152578-GRIA4
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Specifications
- Immunogen
- Human
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human GRIA4
- Species Reactivity
- Human, Mouse, Rat
- Clone
- AibG-Rb-GR450
- Applications
- Western Blot, Flow Cytometry
- Conjugate
- Unconjugated, Biotin and FITC are available.
- Related Disease
- Neurodevelopmental Disorder With Or Without Seizures And Gait Abnormalities and Non-Specific Syndromic Intellectual Disability
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity purified
- Format
- Liquid
- Buffer
- 50 mM Tris-Glycine, pH 7.4, 0.15 M NaCl, 40% Glycerol, 0.05% Protective protein
- Preservative
- 0.01% Sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Applications
- Application Notes
- Western Blot (1:1000-1:5000), Flow Cytometry (1:10-1:100)
Target
- Alternative Names
- GLUR4; GLURD; GluA4; GLUR4C
- Gene ID
- 2893
- UniProt ID
- P48058
- Long Name
- Glutamate Ionotropic Receptor AMPA Type Subunit 4
- Sequence Similarities
- Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
- Cellular Localization
- Cell membrane, Postsynaptic cell membrane, Cell projection, dendrite
- Post Translation Modifications
- Palmitoylated.
Depalmitoylated upon glutamate stimulation.
Cys-611 palmitoylation leads to Golgi retention and decreased cell surface expression.
In contrast, Cys-837 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).
Phosphorylated at Ser-862 by PRKCG; phosphorylation increases plasma membrane-associated GRI4 expression. (P48058-GRIA4_HUMAN)
Glycosylation at Asn52, Asn56, Asn258, Asn371, Asn407, and Asn414 (NX_P48058 [NX_P48058-1])
Modification sites at PhosphoSitePlus (P48058)
Glycosylation from GlyGen (P48058) 6 sites
- Protein Refseq
- XP_005271575.1; XP_006718886.1; XP_011541079.1; XP_016873098.1; XP_016873099.1
- Function
- The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.
In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "GRIA4"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1507 | Rabbit Anti-GRIA4 Recombinant Antibody (clone DS1507AB) | WB, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2916 | Anti-GRIA4 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS14-YC374 | AibGenesis™ Rabbit Anti-GRIA4 Recombinant Antibody (AibG-Rb-RI174) | WB, FC | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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