Llama Anti-GRIN2A Recombinant Antibody (clone Nb-4)
CAT#: VS-0624-FY9
This product is a Lama glama anti-human GluN2A recombinant Single Domain Antibody. The antibody is specific for GluN2A and designated as Nb-4
Gene Expression
Normal Tissue
Figure 1 High expression in cerebral cortex.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/22725/151907_B_9_5_selected.jpg
Normal Tissue
Figure 2 Low expression in kidney.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/22725/151907_A_8_5_val_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/22725/151907_B_9_5.jpg
Normal Tissue
Figure 4 Cerebellum
Bergmann glia - cytoplasm/membrane Staining: Not detected Intensity: Negative Bergmann glia - nucleus Staining: Not detected Intensity: Negative GLUC cells - cytoplasm/membrane Staining: Not detected Intensity: Negative GLUC cells - nucleus Staining: Not detected Intensity: Negative Granular cells - cytoplasm/membrane Staining: Not detected Intensity: Negative Granular cells - nucleus Staining: Not detected Intensity: Negative Molecular layer - neuropil Staining: Not detected Intensity: Negative Molecular layer cells - cytoplasm/membrane Staining: Not detected Intensity: Negative Molecular layer cells - nucleus Staining: Not detected Intensity: Negative Processes in granular layer Staining: Not detected Intensity: Negative Processes in molecular layer Staining: Not detected Intensity: Negative Processes in white matter Staining: Not detected Intensity: Negative Purkinje cells - cytoplasm/membrane Staining: Not detected Intensity: Negative Purkinje cells - dendrites Staining: Not detected Intensity: Negative Purkinje cells - nucleus Staining: Not detected Intensity: Negative Synaptic glomeruli - capsule Staining: Not detected Intensity: Negative Synaptic glomeruli - core Staining: High Intensity: Strong White matter cells - cytoplasm/membrane Staining: Not detected Intensity: Negative White matter cells - nucleus Staining: Not detected Intensity: Negative
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/22725/151907_B_7_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (BJ hTERT+ SV40 Large T+ RasG12V, fHDF/TERT166, hTERT-RPE1, RPMI-8226, U-138 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000183454-GRIN2A
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Specifications
- Host Species
- Llama
- Type
- Lama VHH
- Specificity
- Human GRIN2A
- Species Reactivity
- Human
- Clone
- Nb-4
- Applications
- Immunoassay
- Related Disease
- Epilepsy, Focal, With Speech Disorder And With Or Without Impaired Intellectual Development and Landau-Kleffner Syndrome
Product Property
- Clonality
- Monoclonal Antibody
- Purification
- Ni-NTA Affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Glutamate Ionotropic Receptor NMDA Type Subunit 2A; Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2A; N-Methyl D-Aspartate Receptor Subtype 2A; NMDAR2A; GluN2A; NR2A; N-Methyl-D-Aspartate Receptor Channel, Subunit Epsilon-1; Glutamate [NMDA] Receptor Subunit Epsilon-1
- Gene ID
- 2903
- UniProt ID
- Q12879
- Long Name
- Glutamate Ionotropic Receptor NMDA Type Subunit 2A
- Sequence Similarities
- Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family
- Cellular Localization
- Cell projection, dendritic spine {ECO:0000250 UniProtKB:Q00959}
Cell membrane; Multi-pass membrane protein {ECO:0000269 PubMed:26875626, 26919761, 28105280, 8768735 | ECO:0000305}
Synapse
- Post Translation Modifications
- Glycosylation at Asn75, Asn340, Asn380, Asn443, Asn444, Asn541, and Asn687 (NX_Q12879 [NX_Q12879-1])
Modification sites at PhosphoSitePlus (Q12879)
Glycosylation from GlyGen (Q12879) 8 sites, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_016878661.1; XP_016878662.1; XP_047289949.1; XP_047289950.1; XP_054236123.1
- Function
- Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium.
Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:8768735, 26919761, 26875626, 28105280).
Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have lower sensitivity to glutamate and faster deactivation kinetics than channels formed by GRIN1 and GRIN2B.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "GRIN2A"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3514z | Mouse Anti-GRIN2A Recombinant Antibody (clone 41H1) | WB, ICC, IF, IHC | Mouse IgG2a |
| MRO-1099-CN | Rabbit Anti-GRIN2A Recombinant Antibody (clone JA31-20) | WB, IHC | Rabbit IgG |
| VS3-FY617 | Recombinant Rabbit Anti-Grin2A Antibody (clone R03-2K3) | WB | Rabbit IgG |
| VS7-HM1032 | Mouse Anti-GRIN2A Recombinant Antibody (clone 3G10F9) | FCM | Mouse IgG1 |
| VS13-YC471 | Rabbit Anti-GRIN2A Recombinant Antibody (VS13-YC471) | WB, IHC-P, ICC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1511 | Rabbit Anti-GRIN2A Recombinant Antibody (clone DS1511AB) | WB | Rabbit IgG |
| MOR-0036-FY | Rabbit Anti-GRIN2A Recombinant Antibody (clone AFY0007) | ICC, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2921 | Anti-GRIN2A Immunohistochemistry Kit | IHC | |
| VS-0525-XY2922 | Anti-Mouse GRIN2A Immunohistochemistry Kit | IHC |
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