Llama Anti-GRIN2A Recombinant Antibody (clone Nb-4) (CAT#: VS-0624-FY9)

• Host Species
• Llama

• Type
• Lama VHH

• Specificity
• Human GRIN2A

• Species Reactivity
• Human

• Clone
• Nb-4

• Applications
• Immunoassay

• Related Disease
• Epilepsy, Focal, With Speech Disorder And With Or Without Impaired Intellectual Development and Landau-Kleffner Syndrome

• Clonality
• Monoclonal Antibody

• Purification
• Ni-NTA Affinity purified

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• PBS, pH 7.4

• Preservative
• No preservatives

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Alternative Names
• Glutamate Ionotropic Receptor NMDA Type Subunit 2A; Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2A; N-Methyl D-Aspartate Receptor Subtype 2A; NMDAR2A; GluN2A; NR2A; N-Methyl-D-Aspartate Receptor Channel, Subunit Epsilon-1; Glutamate [NMDA] Receptor Subunit Epsilon-1

• Gene ID
• 2903

• UniProt ID
• Q12879

• Long Name
• Glutamate Ionotropic Receptor NMDA Type Subunit 2A

• Sequence Similarities
• Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family

• Cellular Localization
• Cell projection, dendritic spine {ECO:0000250 UniProtKB:Q00959}
  Cell membrane; Multi-pass membrane protein {ECO:0000269 PubMed:26875626, 26919761, 28105280, 8768735 | ECO:0000305}
  Synapse

• Post Translation Modifications
• Glycosylation at Asn75, Asn340, Asn380, Asn443, Asn444, Asn541, and Asn687 (NX_Q12879 [NX_Q12879-1])
  Modification sites at PhosphoSitePlus (Q12879)
  Glycosylation from GlyGen (Q12879) 8 sites, 1 O-linked glycan (1 site)

• Protein Refseq
• XP_016878661.1; XP_016878662.1; XP_047289949.1; XP_047289950.1; XP_054236123.1

• Function
• Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium.
  Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:8768735, 26919761, 26875626, 28105280).
  Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have lower sensitivity to glutamate and faster deactivation kinetics than channels formed by GRIN1 and GRIN2B.

Secondary Antibody

• 2ND-035CQ
• Goat Anti-Llama IgG (H&L) Antibody

• 2ND-036CQ
• Rabbit Anti-Llama IgG (H&L) Antibody

Isotype Control

• MRO-A1590-YJ
• Llama IgG Isotype control, Polyclonal

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