Recombinant Human Anti-H7N9 HA Antibody (HNIgGA6) (CAT#: PABC-428)
This product is a recombinant Human antibody that can recognize H7N9 HA. Human-originated antibody HNIgGA6 neutralized the H7N9 virus both in vitro and in vivo. The MAb HNIgGA6 targets a highly conserved epitope across the RBS residues, which overlap extensively with the sialic acid receptor binding.
Specific Inquiry
Neut
Figure 1 The neutralizing activities of HNIgGA6 and HNIgGB5 were tested on cells.
An anti-HIV human IgG was used as a negative control.
Chen, C., Liu, Z., Liu, L., Xiao, Y., Wang, J., & Jin, Q. (2018). Broad neutralizing activity of a human monoclonal antibody against H7N9 strains from 2013 to 2017. Emerging microbes & infections, 7(1), 1-9.
FuncS
Figure 2 Prophylactic efficacy of HNIgGA6 and HNIgGB5 in mice.
Mice received HNIgGA6 or HNIgGB5 24 h before H7N9 infection and were monitored daily for 14 days. The survival rate is presented (n =15 per group).
Chen, Z., Wang, J., Bao, L., Guo, L., Zhang, W., Xue, Y., ... & Deng, Y. (2015). Human monoclonal antibodies targeting the haemagglutinin glycoprotein can neutralize H7N9 influenza virus. Nature communications, 6, 6714.
FuncS
Figure 3 Therapeutic treatment against H7N9 infection with HNIgGA6 and HNIgGB5 in mice.
Mice were challenged with a lethal dose of H7N9 virus (n = 15 per group). (a) The infected mice were immunized 3 h.p.i. with HNIgGA6 or HNIgGB5. The survival rate of the mice was monitored daily until 14 d.p.i.
Chen, Z., Wang, J., Bao, L., Guo, L., Zhang, W., Xue, Y., ... & Deng, Y. (2015). Human monoclonal antibodies targeting the haemagglutinin glycoprotein can neutralize H7N9 influenza virus. Nature communications, 6, 6714.
ELISA
Figure 4 Binding of H7N9-AH HA mutants (A138S, S174N, V186G, P221T, and L226Q) to HNIgGA6 was measured by ELISA.
Chen, C., Liu, Z., Liu, L., Xiao, Y., Wang, J., & Jin, Q. (2018). Broad neutralizing activity of a human monoclonal antibody against H7N9 strains from 2013 to 2017. Emerging microbes & infections, 7(1), 1-9.
Specifications
- Host Species
- Human
- Type
- Human IgG1
- Specificity
- H7N9 HA
- Species Reactivity
- Influenza A virus H7N9
- Clone
- HNIgGA6
- Applications
- Neut, FuncS, ELISA
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Storage
- Store at -20°C for long-term storage. Avoid freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Enzyme-linked Immunosorbent Assay, Neutralization and Functional Assay. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. be carefully titrated in specific assays.
Target
- Alternative Names
- H7N9 HA; Influenza A virus H7N9 Hemagglutinin
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3955 | Hi-Affi™ Recombinant Rabbit Anti-H7N9 HA Monoclonal Antibody (SI15DS) | ELISA, FC | IgG |
| MOR-3956 | Hi-Affi™ Recombinant Rabbit Anti-H7N9 HA Monoclonal Antibody (SI16DS) | FC | IgG |
| MOR-3957 | Hi-Affi™ Recombinant Rabbit Anti-H7N9 HA Monoclonal Antibody (SI17DS) | ELISA, FC, HI, MN, B/N | IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0491LY | Recombinant Humanized Anti-H7N9 HA Antibody (2G11) | WB, Neutralization | Mouse |
| PABC-356 | Recombinant Human Anti-H7N9 HA Antibody (L3A-44) | ELISA, Neut | Human IgG |
| PABC-357 | Recombinant Human Anti-H7N9 HA Antibody (L4A-14) | ELISA, Neut | Human IgG |
| PABC-358 | Recombinant Human Anti-H7N9 HA Antibody (L4B-18) | ELISA, Neut | Human IgG |
| PABC-490 | Recombinant Human Anti-H7N9 HA Antibody (H7.167) | ELISA, Neut | Human IgG1, κ |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0491LY-S(P) | Humanized Anti-H7N9 HA Antibody scFv Fragment (2G11) | WB, Neutralization | scFv |
| PSBC-427 | Recombinant Human Anti-H7N9 HA Antibody scFv Fragment (m826) | ELISA | Human scFv |
| PSBC-428 | Recombinant Human Anti-H7N9 HA Antibody scFv Fragment (HNIgGA6) | ELISA, Neut | Human scFv |
| PSBC-490 | Recombinant Human Anti-H7N9 HA Antibody scFv Fragment (H7.167) | ELISA, Neut | Human scFv |
| HPAB-0326-FY-S(P) | Recombinant Human Anti-H7N9 HA Antibody scFv Fragment (mAb910) | N, E, WB, I |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBC-356 | Recombinant Human Anti-H7N9 HA Antibody Fab Fragment (L3A-44) | ELISA, Neut | Human Fab |
| PFBC-357 | Recombinant Human Anti-H7N9 HA Antibody Fab Fragment (L4A-14) | ELISA, Neut | Human Fab |
| PFBC-358 | Recombinant Human Anti-H7N9 HA Antibody Fab Fragment (L4B-18) | ELISA, Neut | Human Fab |
| PFBC-359 | Recombinant Human Anti-H7N9 HA Antibody Fab Fragment (VRC 315 13-1b02) | FC, Neut | Human Fab |
| HPAB-0326-FY-F(E) | Recombinant Human Anti-H7N9 HA Antibody Fab Fragment (mAb910) | N, E, WB, I |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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