Human Anti-HAMP Recombinant Antibody (clone 15E1 N57H) (CAT#: VS-0724-YC27)
Provided is a recombinant antibody 15E1 N57H that binds hepcidin. 15E1 N57H demonstrated lower binding affinity for hepcidin at pH 6.0 compared to pH 7.4.
Specific Inquiry
RNA Expression
Figure 1 RNA cell line category: Cell line enriched (Hep G2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000105697-HAMP
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000105697-HAMP
Specifications
- Immunogen
- KLH-conjugated human hepcidin
- Host Species
- Human
- Derivation
- Hybridoma
- Type
- Human IgG2
- Specificity
- Human hepcidin
- Species Reactivity
- Human
- Clone
- 15E1 N57H
- Applications
- ELISA, SPR
Product Property
- Purification
- Protein A purified
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- HEPC; PLTR; HFE2B; LEAP1
- Gene ID
- 57817
- UniProt ID
- P81172
- Long Name
- Hepcidin
- Sequence Similarities
- Belongs to the hepcidin family.
- Cellular Localization
- Secreted
- Protein Refseq
- NP_066998.1
- Function
- Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues.
Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma.
Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes.
Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria.
Active against the fungus C.albicans.
No activity against P.aeruginosa.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Human Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-430 | Recombinant Anti-human HAMP Antibody | WB, IP, FuncS | IgG |
| MHH-430 | Recombinant Human Anti-human HAMP Antibody | ELISA, WB, IP, FuncS | IgG |
| HPAB-0915-WJ | Mouse Anti-HAMP Recombinant Antibody (HPAB-0915-WJ) | Inhib | Mouse IgG1 |
| ZG-0706J | Rabbit Anti-HAMP Recombinant Antibody (clone 4C5) | ELISA, WB, IHC | Rabbit IgG |
| VS-0224-XY59 | Mouse Anti-HAMP Recombinant Antibody (VS-0224-XY59) | ELISA, WB, ICC, IHC-Fr, IHC-P | Mouse IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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