Mouse Anti-HK2 Recombinant Antibody (VS3-FY2736)
CAT#: VS3-FY2736
The anti-HK2 antibody is a mouse recombinant monoclonal antibody that was designed for the specific binding of mouse Hexokinase II protein. It has been shown to cross-react with monkey and rat species. The monoclonal antibody is particularly valuable for disease research in Pancreatic cancer and Renal Cell Carcinoma, and can also be effectively utilized in Western Blot assay.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to mitochondria.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28587/1912_G4_5_cr5c862f4c55d36_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol & mitochondria.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/61711/1101_E6_1_selected.jpg
Normal Tissue
Figure 3 Epididymis
High expression in epididymis
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28587/60634_A_1_6_val_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28587/60634_B_8_5.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28587/60634_A_7_5.jpg
Normal Tissue
Figure 6 Testis
Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity:>75% Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Sertoli cells Staining: Medium Intensity: Moderate Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28587/60634_A_4_6.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (U-87 MG)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000159399-HK2
❮
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| Sub Cat | Host Animal | Species Reactivity | Application | Application Notes | Size | Conjugation | Endotoxin | Purity | Fc Engineering | |
| VS3-FY2783 | Mouse | Rat, Mouse, Monkey | WB | Western Blot: 1/500-1/1000 | ||||||
| VS3-FY2737 | Rabbit | Human, Rat, Hamster | WB, IHC, IP |
Immunoprecipitation: 1/20 Western Blot: 1/500-1/1000 Immunohistochemistry: 1/50-1/100 |
Specifications
- Type
- Mouse IgG
- Specificity
- Hexokinase 2 of rat, mouse and monkey origins
- Conjugate
- Unconjugated, FITC
- Related Disease
- Pancreatic Cancer and Renal Cell Carcinoma
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Hexokinase 2; Muscle Form Hexokinase; Hexokinase Type II; EC 2.7.1.1; HK II; Hexokinase-2, Muscle
- Gene ID
- 3099
- UniProt ID
- P52789
- Sequence Similarities
- Belongs to the hexokinase family.
- Cellular Localization
- Mitochondrion outer membrane; Peripheral membrane protein
Cytoplasm, cytosol
- Post Translation Modifications
- Ubiquitination at Lys41, Lys62, Lys173, Lys323, Lys488, and Lys899
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 2 sites, 1 O-linked glycan (2 sites)
- Protein Refseq
- XP_005264337.1; XP_011531109.1; XP_016859434.1; XP_047300040.1; XP_047300041.1
- Function
- Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:29298880).
Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "HK2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1615 | Rabbit Anti-HK2 Recombinant Antibody (clone DS1615AB) | WB, IHC-P, IF | Rabbit IgG |
| MOR-4588 | Rabbit Anti-HK2 Recombinant Antibody (clone TH101DS) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0618-WJ | Mouse Anti-HK2 Recombinant Antibody (HPAB-0618-WJ) | IF | Mouse IgG |
| ZG-0420J | Mouse Anti-HK2 Recombinant Antibody (ZG-0420J) | WB | Mouse IgG |
| ZG-0421J | Mouse Anti-HK2 Recombinant Antibody (ZG-0421J) | WB | Mouse IgG |
| VS4-WK220 | Mouse Anti-HK2 Recombinant Antibody (VS4-WK220) | ELISA, WB, FC | Mouse IgG |
| VS7-0425-WR66 | Mouse Anti-HK2 Monoclonal Antibody (VS7-0425-WR66) | WB, IHC-P, IF, FC, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0618-WJ-F(E) | Mouse Anti-HK2 Recombinant Antibody; Fab Fragment (HPAB-0618-WJ-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0618-WJ-S(P) | Mouse Anti-HK2 Recombinant Antibody; scFv Fragment (HPAB-0618-WJ-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY249 | Rabbit Anti-NHP HK2 Recombinant Antibody (VS-1024-XY249) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1027 | Anti-HK2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3162 | Anti-Human HK2 Immunohistochemistry Kit | IHC |
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