Mouse Anti-HK2 Recombinant Antibody (VS3-FY2736) (CAT#: VS3-FY2736)
The anti-HK2 antibody is a mouse recombinant monoclonal antibody that was designed for the specific binding of mouse Hexokinase II protein. It has been shown to cross-react with monkey and rat species. The monoclonal antibody is particularly valuable for disease research in Pancreatic cancer and Renal Cell Carcinoma, and can also be effectively utilized in Western Blot assay.
| Sub Cat | Host Animal | Species Reactivity | Application | Application Notes | Size | Conjugation | Endotoxin | Purity | Fc Engineering | |
| VS3-FY2783 | Mouse | Rat, Mouse, Monkey | WB | Western Blot: 1/500-1/1000 | ||||||
| VS3-FY2737 | Rabbit | Human, Rat, Hamster | WB, IHC, IP |
Immunoprecipitation: 1/20 Western Blot: 1/500-1/1000 Immunohistochemistry: 1/50-1/100 |
More Infomation
Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to mitochondria.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/28587/1912_G4_5_cr5c862f4c55d36_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to mitochondria.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/28587/1912_G4_5_cr5c862f4c55d36_selected.jpg
Figure 2 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol & mitochondria.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/61711/1101_E6_1_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol & mitochondria.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/61711/1101_E6_1_selected.jpg
Figure 3 Epididymis
(High expression in epididymis)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/28587/60634_A_1_6_val_selected.jpg
(High expression in epididymis)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/28587/60634_A_1_6_val_selected.jpg
Figure 4 Cerebral cortex
(Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/28587/60634_B_8_5.jpg
(Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/28587/60634_B_8_5.jpg
Figure 5 Kidney
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/28587/60634_A_7_5.jpg
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/28587/60634_A_7_5.jpg
Figure 6 Testis
(Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity:>75% Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Sertoli cells Staining: Medium Intensity: Moderate Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/28587/60634_A_4_6.jpg
(Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity:>75% Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Sertoli cells Staining: Medium Intensity: Moderate Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/28587/60634_A_4_6.jpg
Figure 7 RNA cell line category: Cell line enhanced (U-87 MG)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000159399-HK2
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000159399-HK2
Specifications
- Type
- Mouse IgG
- Specificity
- Hexokinase 2 of rat, mouse and monkey origins
- Conjugate
- Unconjugated, FITC
- Related Disease
- Pancreatic Cancer and Renal Cell Carcinoma
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Hexokinase 2; Muscle Form Hexokinase; Hexokinase Type II; EC 2.7.1.1; HK II; Hexokinase-2, Muscle
- Gene ID
- 3099
- UniProt ID
- P52789
- Sequence Similarities
- Belongs to the hexokinase family.
- Cellular Localization
- Mitochondrion outer membrane; Peripheral membrane protein
Cytoplasm, cytosol
- Post Translation Modifications
- Ubiquitination at Lys41, Lys62, Lys173, Lys323, Lys488, and Lys899
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 2 sites, 1 O-linked glycan (2 sites)
- Protein Refseq
- XP_005264337.1; XP_011531109.1; XP_016859434.1; XP_047300040.1; XP_047300041.1
- Function
- Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:29298880).
Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1615 | Rabbit Anti-HK2 Recombinant Antibody (clone DS1615AB) | WB, IHC-P, IF | Rabbit IgG |
| MOR-4588 | Rabbit Anti-HK2 Recombinant Antibody (clone TH101DS) | WB | Rabbit IgG |
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