Human Anti-HLA-DR4/GAD-555-567 Recombinant Antibody (clone G3H8) (CAT#: HPAB-0826-FY)

Provided is a human antibody that recognizes HLA-DR4 / GAD-555-567. It can inhibit GAD₅₅₅₋₅₆₇ specific DR0401 restricted T cell hybridoma response.

Specific Inquiry
  • Size:
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  • Fc Engineering:
  • Published Data
  • Tested Data
  • Datasheet
  • MSDS
  • COA
FC

Figure 1. Flow cytometry analysis of G3H8 Fab anti-HLA-DR Ab binding to Preiss cells pulsed with GAD-555-567 peptide.

Figure 1. Flow cytometry analysis of G3H8 Fab anti-HLA-DR Ab binding to Preiss cells pulsed with GAD-555-567 peptide.

Dahan, R., Gebe, J. A., Preisinger, A., James, E. A., Tendler, M., Nepom, G. T., & Reiter, Y. (2013). Antigen-specific immunomodulation for type 1 diabetes by novel recombinant antibodies directed against diabetes-associates auto-reactive T cell epitope. Journal of autoimmunity, 47, 83-93.

IF

Figure 2. Immunofluorescence staining of Preiss cells that were loaded with GAD-555e567 or HA-306e318 peptides. Cells were stained with anti-HLA-DR (green) or G3H8 TCRL (red).

Figure 2. Immunofluorescence staining of Preiss cells that were loaded with GAD-555e567 or HA-306e318 peptides. Cells were stained with anti-HLA-DR (green) or G3H8 TCRL (red).

Dahan, R., Gebe, J. A., Preisinger, A., James, E. A., Tendler, M., Nepom, G. T., & Reiter, Y. (2013). Antigen-specific immunomodulation for type 1 diabetes by novel recombinant antibodies directed against diabetes-associates auto-reactive T cell epitope. Journal of autoimmunity, 47, 83-93.


Specifications

  • Host Species
  • Human
  • Type
  • Human IgG
  • Specificity
  • Human HLA-DR4/GAD-555-567
  • Species Reactivity
  • Human
  • Clone
  • G3H8
  • Applications
  • FC

Product Property

  • Purification
  • Protein A/G Purified
  • Purity
  • >95% as determined by SDS-PAGE
  • Concentration
  • See the COA
  • Buffer
  • PBS
  • Storage
  • Store at 4°C for short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Applications

  • Application Notes
  • This antibody has been reported for use in Flow Cytometry.

Target

  • Alternative Names
  • HLA-DR4/GAD-555-567; HLA-DR4; GAD-555-567; HLA-DR4/GAD555-567

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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To accurately reference this product in your publication, please use the following citation information:

(Creative Biolabs Cat# HPAB-0826-FY, RRID: AB_3111410)

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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