Provided is a human antibody that recognizes HLA-DR4 / GAD-555-567. It can inhibit GAD₅₅₅₋₅₆₇ specific DR0401 restricted T cell hybridoma response.
Figure 1. Flow cytometry analysis of G3H8 Fab anti-HLA-DR Ab binding to Preiss cells pulsed with GAD-555-567 peptide.
Dahan, R., Gebe, J. A., Preisinger, A., James, E. A., Tendler, M., Nepom, G. T., & Reiter, Y. (2013). Antigen-specific immunomodulation for type 1 diabetes by novel recombinant antibodies directed against diabetes-associates auto-reactive T cell epitope. Journal of autoimmunity, 47, 83-93.
Figure 2. Immunofluorescence staining of Preiss cells that were loaded with GAD-555e567 or HA-306e318 peptides. Cells were stained with anti-HLA-DR (green) or G3H8 TCRL (red).
Dahan, R., Gebe, J. A., Preisinger, A., James, E. A., Tendler, M., Nepom, G. T., & Reiter, Y. (2013). Antigen-specific immunomodulation for type 1 diabetes by novel recombinant antibodies directed against diabetes-associates auto-reactive T cell epitope. Journal of autoimmunity, 47, 83-93.
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• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0827-FY | Human Anti-HLA-DR4/GAD-555-567 Recombinant Antibody (clone G1H12) | FC | Human IgG |
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(Creative Biolabs Cat# HPAB-0826-FY, RRID: AB_3111410)
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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