Rabbit Anti-HPGD Recombinant Antibody (VS13-YC548) (CAT#: VS13-YC548)
The Rabbit Anti-HPGD Recombinant Antibody is specific for human HPGD. HPGD, part of a short-chain dehydrogenase family, metabolizes prostaglandins affecting physiological processes and is linked to conditions like hypertrophic osteoarthropathy with multiple transcript variants. The anti-HPGD antibody can be used for Immunohistochemistry (1/100-1/200).
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5679/10_A5_1_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5679/10_A5_1_selected.jpg
Figure 2 Testis
(Leydig cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5679/20208_A_4_6.jpg
(Leydig cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5679/20208_A_4_6.jpg
Figure 3 Colon
(Endocrine cells Staining: Medium Intensity: Moderate Enterocytes Staining: Medium Intensity: Moderate Quantity:>75% Enterocytes -)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5679/20208_A_7_3.jpg
(Endocrine cells Staining: Medium Intensity: Moderate Enterocytes Staining: Medium Intensity: Moderate Quantity:>75% Enterocytes -)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5679/20208_A_7_3.jpg
Figure 4 Liver
(Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5679/20208_A_9_4.jpg
(Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5679/20208_A_9_4.jpg
Figure 5 Kidney
(Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5679/20208_A_9_5.jpg
(Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5679/20208_A_9_5.jpg
Figure 6 Urinary bladder
(Urothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5679/20208_A_5_5.jpg
(Urothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5679/20208_A_5_5.jpg
Figure 7 RNA cell line category: Cell line enhanced (A549, ASC diff, HEL, OE19, RT4, SuSa)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000164120-HPGD
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000164120-HPGD
Specifications
- Immunogen
- Recombinant human 15-PGDH.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human HPGD
- Species Reactivity
- Human
- Applications
- IHC-P
- Conjugate
- NONE
- Related Disease
- Hypertrophic Osteoarthropathy, Autosomal Recessive
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity Chromatography purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS (pH 7.9) containing 50% Glycerol and 0.5% BSA.
- Preservative
- 0.02% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Immunohistochemistry (IHC): 1/100-1/200
Target
- Alternative Names
- 15-Hydroxyprostaglandin Dehydrogenase; Short Chain Dehydrogenase/Reductase Family 36C Member 1; 15-Hydroxyprostaglandin Dehydrogenase (NAD(+)); Hydroxyprostaglandin Dehydrogenase 15-(NAD); Prostaglandin Dehydrogenase 1; EC 1.1.1.141; 15-PGDH; SDR36C1;
- Gene ID
- 3248
- UniProt ID
- P15428
- Long Name
- 15-Hydroxyprostaglandin Dehydrogenase
- Cellular Localization
- Cytoplasm
- Protein Refseq
- NP_000851.2
- Function
- Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites (PubMed:8086429, 10837478, 16828555, 16757471, 21916491, 25586183).
Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression (PubMed:25586183, 15574495).
Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation.
Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Rabbit Monoclonal Antibody Products
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Antibody Magnetic Beads
IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1669 | Rabbit Anti-HPGD Recombinant Antibody (clone DS1669AB) | WB | Rabbit IgG |
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