Rabbit Anti-HPGD Recombinant Antibody (clone R04-5I2) (CAT#: VS3-XY3385)

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human HPGD

• Species Reactivity
• Human

• Clone
• R04-5I2

• Applications
• WB, IHC-P, ICC, IF, FC

• Related Disease
• Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 1

• Clonality
• Monoclonal

• Aggregation
• < 5%

• Format
• Liquid

• Buffer
• PBS (pH 7.4), 150 mM NaCl and 50% glycerol

• Preservative
• 0.02% sodium azide

• Storage
• Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• WB: 1/500-1/1000
  IHC: 1/50-1/100
  IF: 1/50-1/200
  FC: 1/50-1/100

• Alternative Names
• PGDH; PGDH1; PHOAR1; 15-PGDH; SDR36C1

• Gene ID
• 3248

• UniProt ID
• P15428

• Long Name
• 15-hydroxyprostaglandin dehydrogenase

• Cellular Localization
• Cytoplasm

• Post Translation Modifications
• Modification sites at PhosphoSitePlus (P15428)
  Modification sites at neXtProt (NX_P15428)

• Protein Refseq
• NP_000851.2

• Function
• Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites (PubMed:8086429, 10837478, 16828555, 16757471, 21916491, 25586183).
  Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression (PubMed:25586183, 15574495).
  Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation.
  Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Recommended Dilution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS

Secondary Antibody

• 2RD-A1473-YJ
• Goat Anti-Rabbit IgG-F(ab')2 Secondary antibody

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