Recombinant Human Anti-HSV Antibody (AC8) (CAT#: HPAB-J0123-YC)
Provided is a neutralizing antibody employed in the study which immunoreacts with glycoprotein D of Herpes simplex virus. The antibody can be used in ELISA and Inhibition.
Specific Inquiry
Neut
Figure 1 Neutralization of low-passage clinical isolates by human recombinant MAb HSV8.
These concentrations are comparable to those required for HSV8 neutralization of laboratory strains of HSV-1 and -2.
De Logu, A., Williamson, R. A., Rozenshteyn, R., Ramiro-Ibañez, F., Simpson, C. D., Burton, D. R., & Sanna, P. P. (1998). Characterization of a type-common human recombinant monoclonal antibody to herpes simplex virus with high therapeutic potential. Journal of Clinical Microbiology, 36(11), 3198-3204.
Inhib
Figure 2 Syncytial inhibition as a function of HSV8 concentration.
At the higher concentrations tested (8 and 16 mg/ml), syncytium formation was completely prevented.
De Logu, A., Williamson, R. A., Rozenshteyn, R., Ramiro-Ibañez, F., Simpson, C. D., Burton, D. R., & Sanna, P. P. (1998). Characterization of a type-common human recombinant monoclonal antibody to herpes simplex virus with high therapeutic potential. Journal of Clinical Microbiology, 36(11), 3198-3204.
IHC
Figure 3 Inhibition of syncytium formation by human recombinant MAb HSV8.
HSV8 was effective in completely abolishing syncytium formation.
De Logu, A., Williamson, R. A., Rozenshteyn, R., Ramiro-Ibañez, F., Simpson, C. D., Burton, D. R., & Sanna, P. P. (1998). Characterization of a type-common human recombinant monoclonal antibody to herpes simplex virus with high therapeutic potential. Journal of Clinical Microbiology, 36(11), 3198-3204.
WB
Figure 4 Epitope mapping of human recombinant MAb HSV8.
MAb H170, specific for the continuous group VII antigenic site, were used as controls.
De Logu, A., Williamson, R. A., Rozenshteyn, R., Ramiro-Ibañez, F., Simpson, C. D., Burton, D. R., & Sanna, P. P. (1998). Characterization of a type-common human recombinant monoclonal antibody to herpes simplex virus with high therapeutic potential. Journal of Clinical Microbiology, 36(11), 3198-3204.
ELISA
Figure 5 Since human recombinant MAb HSV8 is directed to a discontinuous determinant, epitope mapping was carried out by competition with known antibodies in two ELISA configurations.
The y axis represents optical density (O.D.).
De Logu, A., Williamson, R. A., Rozenshteyn, R., Ramiro-Ibañez, F., Simpson, C. D., Burton, D. R., & Sanna, P. P. (1998). Characterization of a type-common human recombinant monoclonal antibody to herpes simplex virus with high therapeutic potential. Journal of Clinical Microbiology, 36(11), 3198-3204.
Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- HSV
- Species Reactivity
- HSV
- Clone
- AC8
- Applications
- Neut, WB, ELISA, Inhib, IHC
Product Property
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles
Applications
- Application Notes
- The HSV antibody has been reported in applications of Western Blot, Neutralization, Enzyme-linked Immunosorbent Assay, Inhibition, Immunohistochemistry.
Target
- Alternative Names
- Herpes simplex virus
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Fab Antibody Products
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IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-518-F(E) | Recombinant Anti-HSV Antibody Fab Fragment | WB, Neut, FuncS | Fab |
| MHH-518-F(E) | Recombinant Human Anti-HSV Antibody Fab Fragment | Neut, IF, FuncS | Fab |
| HPAB-0808-CN-F(E) | Human Anti-HSV Recombinant Antibody; Fab Fragment (HPAB-0808-CN-F(E)) | WB, ELISA, IF | Human Fab |
| HPAB-0809-CN-F(E) | Human Anti-HSV Recombinant Antibody; Fab Fragment (HPAB-0809-CN-F(E)) | WB, ELISA, IF | Human Fab |
| HPAB-J0123-YC-F(E) | Recombinant Human Anti-HSV Antibody Fab Fragment (AC8) | ELISA, Inhib | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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