Recombinant Human Anti-HSV Antibody (AC8) (CAT#: HPAB-J0123-YC)
Provided is a neutralizing antibody employed in the study which immunoreacts with glycoprotein D of Herpes simplex virus. The antibody can be used in ELISA and Inhibition.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Neut
Figure 1 Neutralization of low-passage clinical isolates by human recombinant MAb HSV8.
These concentrations are comparable to those required for HSV8 neutralization of laboratory strains of HSV-1 and -2.
De Logu, A., Williamson, R. A., Rozenshteyn, R., Ramiro-Ibañez, F., Simpson, C. D., Burton, D. R., & Sanna, P. P. (1998). Characterization of a type-common human recombinant monoclonal antibody to herpes simplex virus with high therapeutic potential. Journal of Clinical Microbiology, 36(11), 3198-3204.
Inhib
Figure 2 Syncytial inhibition as a function of HSV8 concentration.
At the higher concentrations tested (8 and 16 mg/ml), syncytium formation was completely prevented.
De Logu, A., Williamson, R. A., Rozenshteyn, R., Ramiro-Ibañez, F., Simpson, C. D., Burton, D. R., & Sanna, P. P. (1998). Characterization of a type-common human recombinant monoclonal antibody to herpes simplex virus with high therapeutic potential. Journal of Clinical Microbiology, 36(11), 3198-3204.
IHC
Figure 3 Inhibition of syncytium formation by human recombinant MAb HSV8.
HSV8 was effective in completely abolishing syncytium formation.
De Logu, A., Williamson, R. A., Rozenshteyn, R., Ramiro-Ibañez, F., Simpson, C. D., Burton, D. R., & Sanna, P. P. (1998). Characterization of a type-common human recombinant monoclonal antibody to herpes simplex virus with high therapeutic potential. Journal of Clinical Microbiology, 36(11), 3198-3204.
WB
Figure 4 Epitope mapping of human recombinant MAb HSV8.
MAb H170, specific for the continuous group VII antigenic site, were used as controls.
De Logu, A., Williamson, R. A., Rozenshteyn, R., Ramiro-Ibañez, F., Simpson, C. D., Burton, D. R., & Sanna, P. P. (1998). Characterization of a type-common human recombinant monoclonal antibody to herpes simplex virus with high therapeutic potential. Journal of Clinical Microbiology, 36(11), 3198-3204.
ELISA
Figure 5 Since human recombinant MAb HSV8 is directed to a discontinuous determinant, epitope mapping was carried out by competition with known antibodies in two ELISA configurations.
The y axis represents optical density (O.D.).
De Logu, A., Williamson, R. A., Rozenshteyn, R., Ramiro-Ibañez, F., Simpson, C. D., Burton, D. R., & Sanna, P. P. (1998). Characterization of a type-common human recombinant monoclonal antibody to herpes simplex virus with high therapeutic potential. Journal of Clinical Microbiology, 36(11), 3198-3204.
Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- HSV
- Species Reactivity
- HSV
- Clone
- AC8
- Applications
- Neut, WB, ELISA, Inhib, IHC
Product Property
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles
Applications
- Application Notes
- The HSV antibody has been reported in applications of Western Blot, Neutralization, Enzyme-linked Immunosorbent Assay, Inhibition, Immunohistochemistry.
Target
- Alternative Names
- Herpes simplex virus
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Fab Antibodies
IgG Antibodies
ScFv Antibodies
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-518-F(E) | Recombinant Anti-HSV Antibody Fab Fragment | WB, Neut, FuncS | Fab |
| MHH-518-F(E) | Recombinant Human Anti-HSV Antibody Fab Fragment | Neut, IF, FuncS | Fab |
| HPAB-N0138-YC-F(E) | Human Anti-HSV Recombinant Antibody; Fab Fragment (HPAB-N0138-YC-F(E)) | ELISA | Human Fab |
| HPAB-0026-YJ-F(E) | Recombinant Human Anti-HSV Antibody Fab Fragment (HX8) | Neut, IP | Human Fab |
| HPAB-J0123-YC-F(E) | Recombinant Human Anti-HSV Antibody Fab Fragment (AC8) | ELISA, Inhib | Human Fab |
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