Human Anti-HYOU1 Recombinant Antibody Hexamer (VS-0924-YC132), CDC Enhanced (CAT#: VS-0924-YC132)
The product is a human anti-HYOU1 antibody hexamer with enhanced complement-dependent cytotoxicity (CDC) activity. This hexameric IgG1 targets human HYOU1 and includes hexamerization-enhancing mutations. These mutations promote the formation of hexamers, which mediate optimal C1q binding and enhance CDC.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 IHC staining of human pancreas
(Immunohistochemical staining of human pancreas shows distinct cytoplasmic positivity in exocrine glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49296/ihc_selected.jpg
(Immunohistochemical staining of human pancreas shows distinct cytoplasmic positivity in exocrine glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49296/ihc_selected.jpg
Figure 2 Cerebral cortex
(Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49296/109950_B_8_5.jpg
(Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49296/109950_B_8_5.jpg
Figure 3 Colon
(Glandular cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49296/109950_A_9_3.jpg
(Glandular cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49296/109950_A_9_3.jpg
Figure 4 Pancreas
(Exocrine glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Pancreatic endocrine cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49296/109950_A_2_3.jpg
(Exocrine glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Pancreatic endocrine cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49296/109950_A_2_3.jpg
Figure 5 Testis
(Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49296/109950_A_6_6.jpg
(Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49296/109950_A_6_6.jpg
Figure 6 Lymph node
(Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49296/109950_A_9_8.jpg
(Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49296/109950_A_9_8.jpg
Figure 7 RNA cell line category: Cell line enhanced (EFO-21)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000149428-HYOU1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000149428-HYOU1
Specifications
- Immunogen
- The RPMI8226 cell membrane
- Host Species
- Human
- Type
- Antibody hexamer
- Specificity
- Human HYOU1
- Species Reactivity
- Human
- Molecule Class
- ~ 900 kDa
- Applications
- CDC
- Conjugate
- None
- Related Disease
- Cancer
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Purity
- >95% determined as SDS-PAGE and SEC-HPLC
- Aggregation
- <5%
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Hypoxia Up-Regulated 1; 170 KDa Glucose-Regulated Protein; 150 KDa Oxygen-Regulated Protein; GRP-170; ORP-150; Grp170
- Gene ID
- 10525
- UniProt ID
- Q9Y4L1
- Long Name
- Hypoxia Up-Regulated 1
Downloads
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Hexamer Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1502CT | Recombinant Mouse anti-Human HYOU1 Monoclonal antibody (EML1057) | IHC-P, WB | |
| HPAB-0735-CN | Human Anti-HYOU1 Recombinant Antibody (clone h5F4Ac.2/v17) | WB, ELISA, IP, FC | Humanized IgG3, κ |
| HPAB-AP669-YC | Mouse Anti-HYOU1 Recombinant Antibody (clone 3B6.1) | Apop, CDC, FC | Mouse IgM, κ |
| HPAB-AP670-YC | Mouse Anti-HYOU1 Recombinant Antibody (clone 6A4.28) | Apop, CDC, FC | Mouse IgM, κ |
| HPAB-AP671-YC | Mouse Anti-HYOU1 Recombinant Antibody (clone 9A6.2) | Apop, CDC, FC | Mouse IgM, κ |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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