Rabbit Anti-IDE Recombinant Antibody (VS13-YC566) (CAT#: VS13-YC566)
The Rabbit Anti-IDE Recombinant Antibody is specific for human and mouse IDE. IDE is a zinc metallopeptidase degrading insulin and peptides impacting signaling, with dysfunctions linked to diseases such as Alzheimer's, lacking causative mutations for diabetes. The anti-IDE antibody can be used for Western blot (1/1000-1/2000), Immunohistochemistry-paraffin (1/50-1/200).
Specific Inquiry
Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Normal Tissue
RNA Expression
Figure 1 IHC staining of human stomach
(Immunohistochemical staining of human stomach shows membranous and cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_A_1_1_selected.jpg
(Immunohistochemical staining of human stomach shows membranous and cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_A_1_1_selected.jpg
Figure 2 Cerebral cortex
(Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membrano)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_B_8_5.jpg
(Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membrano)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_B_8_5.jpg
Figure 3 Colon
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_A_7_3.jpg
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_A_7_3.jpg
Figure 4 Liver
(Cholangiocytes
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_A_9_4.jpg
(Cholangiocytes
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_A_9_4.jpg
Figure 5 Kidney
(Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_A_8_5.jpg
(Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_A_8_5.jpg
Figure 6 Testis
(Sertoli cells
Staining: Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_A_6_6.jpg
(Sertoli cells
Staining: Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_A_6_6.jpg
Figure 7 Skin
(Melanocytes
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membrano)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_B_7_1.jpg
(Melanocytes
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membrano)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_B_7_1.jpg
Figure 8 Lymph node
(Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_A_8_8.jpg
(Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/63478/143063_A_8_8.jpg
Figure 9 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000119912-IDE
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000119912-IDE
Specifications
- Immunogen
- Recombinant human insulin degrading enzyme, aa 1-106.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Mouse IDE
- Species Reactivity
- Human, Mouse
- Applications
- WB, IHC-P
- Conjugate
- NONE
- Related Disease
- Alzheimer's disease and type 2 diabetes mellitus
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/1000-1/2000
Immunohistochemistry-paraffin (IHC-P): 1/50-1/200
Target
- Alternative Names
- Insulin Degrading Enzyme
- Gene ID
- 3416
- UniProt ID
- P14735
- Long Name
- Insulin Degrading Enzyme
- Sequence Similarities
- Belongs to the peptidase M16 family.
- Cellular Localization
- Secreted; Cytoplasm; Cell membrane
- Protein Refseq
- XP_016871676.1; XP_016871677.1; XP_016871679.2; XP_047281125.1; XP_047281127.1
- Function
- Plays a role in the degradation and clearance of APP-derived amyloidogenic peptides that are secreted by neurons and microglia. Degrades the natriuretic peptides ANP, BNP and CNP, inactivating their ability to raise intracellular cGMP.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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IgG Antibody Products
Fab Antibody Products
ScFv Antibody Products
Human Antibody Products
Rabbit Monoclonal Antibody Products
Non-Human Primate (NHP) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-535 | Recombinant Anti-human IDE Antibody | WB, Dot, FuncS | IgG |
| PABL-594 | Mouse Anti-IDE Recombinant Antibody (clone YC112) | WB, FuncS | Mouse IgG |
| FAMAB-1164CQ | Human Anti-IDE Recombinant Antibody (clone Fab-IDE) | ELISA | Human IgG1 |
| MOB-0051F | Mouse Anti-IDE Recombinant Antibody (clone 3H4) | WB, IHC-P, IF | Mouse IgG |
| VS3-CJ656 | Mouse Anti-IDE Recombinant Antibody (VS3-CJ656) | WB, IHC | Mouse IgG |
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