Mouse Anti-IDH3G Recombinant Antibody (clone 2506W14)
CAT#: VS-0625-FY32
The Mouse IgG1 monoclonal antibody, clone 2506W14, specifically targets human IDH3G. Its immunogen is a recombinant Rat IDH3G fusion protein, with an epitope mapping to amino acids 363-389. With an approximate antigen size of 45 kDa, this antibody is suitable for Western Blot, Immunoprecipitation, Immunofluorescence, and ELISA, providing reliable detection for IDH3G.
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Specific for an epitope mapping to amino acids 363-389, located at the C-terminus of human IDH3G.
- Species Reactivity
- Human
- Clone
- 2506W14
- Applications
- Western Blot, Immunoprecipitation, Immunofluorescence, ELISA
- Related Disease
- D-2-Hydroxyglutaric Aciduria 2 and Juxtacortical Chondroma
Product Property
- Purification
- Purified with Protein A or G affinity chromatography
- Purity
- >90% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Optimal dilutions for assays should be determined by the user.
Target
- Alternative Names
- Isocitrate Dehydrogenase 3 (NAD(⁺)) Gamma
- Gene ID
- 3421
- UniProt ID
- P51553
- Long Name
- Isocitrate Dehydrogenase 3 (NAD(⁺)) Gamma
- Sequence Similarities
- Belongs to the isocitrate and isopropylmalate dehydrogenases family.
- Cellular Localization
- Mitochondrion
- Post Translation Modifications
- Modification sites at PhosphoSitePlus
Modification sites at neXtProt
Glycosylation
- Protein Refseq
- NP_004126.1; NP_777358.1
- Function
- Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate.
The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
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