Anti-IGF1 Antibody Prodrug, Protease Activated (VS-1025-YC205)
CAT#: VS-1025-YC205
The Anti-IGF1 Antibody Prodrug, Protease Activated (VS-1025-YC205) is an antibody prodrug comprised of a recombinant mouse antibody targeting human IGF1, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to IGF1 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to IGF1 effectively. IGF1 is a potent growth factor whose signaling, mediated by the IGF1 Receptor (IGF1R), acts as a significant promoter of tumor cell proliferation and survival.2 Elevated levels of circulating IGF1 and/or receptor activation are associated with increased cancer risk and progression in many tumors, including breast, prostate, and colon cancers. This pathway often helps cancer cells evade apoptosis and is a key mediator of resistance to chemotherapy and radiotherapy.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human colon
Immunohistochemical staining of human colon shows plasma positivity.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/ihc_selected.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/110992_A_7_3.jpg
Normal Tissue
Figure 3 Rectum
Glandular cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/110992_A_4_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/110992_A_9_4.jpg
Normal Tissue
Figure 5 Testis
Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/110992_A_4_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (ASC diff, HDLM-2, K-562, Karpas-707, U-266/70)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000017427-IGF1/
❮
❯
Specifications
- Host Animal
- Mouse
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human IGF1
- Target
- IGF1
- Species Reactivity
- Human
- Isotype
- IgG
- Epitope
- AA 74-90
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein.
- Alternative Names
- MGF; IGFI; IGF-I
- Gene ID
- 3479
- UniProt ID
- P05019
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-1025-YC205. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Related Signaling Pathways
Insulin Signaling Pathway
Related Diseases
Endocrine Resistance
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "IGF1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1353z | Mouse Anti-IGF1 Recombinant Antibody (clone 23C1) | FC, IF, Neut | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-385CL | Anti-Human IGF1 Recombinant Antibody (TAB-385CL) | WB, FuncS | Antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0151MZ | Recombinant Mouse Anti-IGF-I Somatomedin C Antibody (clone CM24) | RIA, ELISA | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1072CQ | Mouse Anti-IGF1 Recombinant Antibody (clone M23) | Neut, FC, ICC, IF | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1073CQ | Mouse Anti-IGF1 Recombinant Antibody (clone SPM406) | WB, Neut, FC, ICC, IF, IHC-P, IP | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1074CQ | Hamster Anti-Igf1 Recombinant Antibody (clone CBL534) | WB, ELISA, Neut | Hamster IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1754 | Rabbit Anti-IGF1 Recombinant Antibody (clone DS1754AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0038-YC | Mouse Anti-IGF1 Recombinant Antibody (HPAB-0038-YC) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0039-YC | Human Anti-IGF1 Recombinant Antibody (HPAB-0039-YC) | ELISA, Stim, Neut | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0038-YC-S(P) | Mouse Anti-IGF1 Recombinant Antibody; scFv Fragment (HPAB-0038-YC-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0039-YC-S(P) | Human Anti-IGF1 Recombinant Antibody; scFv Fragment (HPAB-0039-YC-S(P)) | ELISA, Stim, Neut | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0038-YC-F(E) | Mouse Anti-IGF1 Recombinant Antibody; Fab Fragment (HPAB-0038-YC-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0039-YC-F(E) | Human Anti-IGF1 Recombinant Antibody; Fab Fragment (HPAB-0039-YC-F(E)) | ELISA, Stim, Neut | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0770-CN | Human Anti-IGF1 Recombinant Antibody (HPAB-0770-CN) | WB, FC | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0770-CN-S(P) | Human Anti-IGF1 Recombinant Antibody; scFv Fragment (HPAB-0770-CN-S(P)) | WB, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0771-CN-S(P) | Human Anti-IGF1 Recombinant Antibody; scFv Fragment (HPAB-0771-CN-S(P)) | WB, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0770-CN-F(E) | Human Anti-IGF1 Recombinant Antibody; Fab Fragment (HPAB-0770-CN-F(E)) | WB, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0771-CN-F(E) | Human Anti-IGF1 Recombinant Antibody; Fab Fragment (HPAB-0771-CN-F(E)) | WB, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0038LY-S(P) | Human Anti-IGF1 Recombinant Antibody; scFv Fragment (HPAB-0038LY-S(P)) | WB | Human scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0038LY-F(E) | Human Anti-IGF1 Recombinant Antibody; Fab Fragment (HPAB-0038LY-F(E)) | WB | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0897 | PE-H-2Db/Human IGF1 (SHLVEALYL) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0898 | APC-H-2Db/Human IGF1 (SHLVEALYL) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0899 | FITC-H-2Db/Human IGF1 (SHLVEALYL) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0900 | H-2Db/Human IGF1 (SHLVEALYL) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY73 | Human Anti-IGF1 (clone Cixutumumab) scFv-Fc Chimera | ELISA, FC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3427 | Anti-IGF1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3428 | Anti-Mouse IGF1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3429 | Anti-Rabbit IGF1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC156 | Recombinant Anti-IGF1 Eliminating Antibody, pH-Sensitive (VS-0625-YC156) | Antigen-Sweeping In Vivo. | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC166 | SmartAb™ Recombinant Anti-IGF1 pH-dependent Antibody (Clone MuEM164) | FC, ELISA, Inhib, Cyt | Mouse IgG |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: WB, ELISA, IP, FC, FuncS, Neut, IF
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: ELISA, IHC
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
Application: WB, FC, IP, ELISA, Neut, FuncS, IF
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: Block, Cyt, FuncS, Inhib
Application: Neut, ELISA, FuncS
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
