SmartAb™ Recombinant Anti-IGF1 pH-dependent Antibody (Clone MuEM164)
CAT#: VS-0825-YC166
The anti-IGF1 pH-dependent antibody (clone MuEM164) is a recombinant monoclonal antibody that exhibits pH-dependent antigen binding to human IGF1. By introducing histidine mutations that act as a pH-switch, the antibody demonstrates a preferential affinity for IGF1 under acidic conditions compared to physiological pH. Using a yeast surface display system with pH-dependent screening pressure, this mAb is identified which shows a significant increase in dissociation from IGF1 at pH 6.0. This pH-sensitive antibody retains its binding affinity for IGF1 on tumor cells while exhibiting negligible binding to the receptor on normal cells at physiological pH. Human IGF1, or Insulin-like Growth Factor 1, is a hormone with structural similarity to insulin that is involved in cell growth and proliferation. It plays a key role in childhood growth and has anabolic effects in adults.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human colon
Immunohistochemical staining of human colon shows plasma positivity.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/ihc_selected.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/110992_A_7_3.jpg
Normal Tissue
Figure 3 Rectum
Glandular cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/110992_A_4_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/110992_A_9_4.jpg
Normal Tissue
Figure 5 Testis
Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/110992_A_4_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (ASC diff, HDLM-2, K-562, Karpas-707, U-266/70)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000017427-IGF1/
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human IGF1
- Species Reactivity
- Human
- Clone
- MuEM164
- Applications
- FC, ELISA, Inhib, Cyt
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Purity
- >95%, determined by SDS-PAGE and SEC-HPLC
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- For short-term storage, keep it at 4°C for up to two weeks. For long-term storage, divide the solution into aliquots and freeze them at -20°C or below.
Target
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Related Signaling Pathways
Insulin Signaling Pathway
Related Diseases
Endocrine Resistance
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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