Anti-IGFBP2 (clone W24V105) Recombinant Antibody Coupled Liposome (VS-1024-FY107)
CAT#: VS-1024-FY107
The innovative application of anti-IGFBP2 antibodies, when combined with liposomal delivery systems, has shown great promise in glioma research by effectively inhibiting tumor growth and metastasis. This strategy capitalizes on the unique ability of antibodies to selectively bind to tumor-associated IGFBP2, a protein often overexpressed in glioma cells, enhancing the precision of treatment. By harnessing this targeted approach, researchers aim to improve therapeutic efficacy and minimize off-target effects, ultimately leading to better outcomes in patients suffering from aggressive brain tumors.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to endoplasmic reticulum.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/77723/1615_H9_6_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (ASC diff, HMC-1, NB-4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000115457-IGFBP2
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More Infomation
Specifications
- Potential Clinical Applications
- Glioma
Product Composition
- Clone
- W24V105
- Antibody Type
- IgG
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant human monoclonal antibody that exhibits specificity for human insulin-like growth factor-binding protein 2 (IGFBP2). As a targeted therapeutic agent, this antibody has been engineered to selectively bind to IGFBP2, a protein involved in various physiological processes, including cellular growth, differentiation, and apoptosis.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- IGFBP2
- Introduction
- The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene.
- Alternative Names
- Insulin Like Growth Factor Binding Protein 2
- Full Name
- Insulin Like Growth Factor Binding Protein 2
- Gene ID
- 3485
- UniProt ID
- P18065
- Cellular Localization
- Secreted
- Post Translation Modifications
- O-glycosylated. ( P18065-IBP2_HUMAN )
Modification sites at PhosphoSitePlus ( P18065 )
Modification sites at neXtProt ( NX_P18065 )
Glycosylation from GlyGen (P18065) 2 sites, 2 O-linked glycans (2 sites)
- Protein Refseq
- NP_000588.3; NP_001300919.1; NP_001300921.1; NP_001300922.1
- Function
- Inhibits IGF-mediated growth and developmental rates.
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture.
They alter the interaction of IGFs with their cell surface receptors.
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Datasheet
MSDS
COA
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| MOB-545 | Recombinant Anti-human IGFBP2 Antibody | ELISA, WB, IP, FuncS | IgG |
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| MOB-545-F(E) | Recombinant Anti-human IGFBP2 Antibody Fab Fragment | WB, IF, FuncS | Fab |
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| CAT | Product Name | Application | Type |
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| MOB-545-S(P) | Recombinant Anti-human IGFBP2 Antibody scFv Fragment | ELISA, WB, Neut, FuncS | scFv |
| MHH-545-S(P) | Recombinant Human Anti-human IGFBP2 Antibody scFv Fragment | ELISA, WB, IF, FuncS | scFv |
| HPAB-0401-YC-S(P) | Mouse Anti-IGFBP2 Recombinant Antibody; scFv Fragment (HPAB-0401-YC-S(P)) | ELISA, Neut, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| VS-0724-YC911 | AbPlus™ Anti-IGFBP2 Magnetic Beads (VS-0724-YC911) | IP, Protein Purification | |
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| CAT | Product Name | Application | Type |
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| VS-0325-XY1107 | Anti-IGFBP2 Immunohistochemistry Kit | IHC | |
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| CAT | Product Name | Application | Type |
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