Rabbit Anti-IGFBP6 Recombinant Antibody (clone R02-6G2)
CAT#: VS3-FY1746
This anti-IGFBP6 antibody detected positive in western blot analysis of IGFBP6 in K562, Hela lysates. The recombinant monoclonal antibody demonstrates specificity in binding to human IGFBP6 protein, a calculated weight of 25 kDa.
Gene Expression
Tested Data
Normal Tissue
Figure 1 IHC staining of human fallopian tube
Immunohistochemical staining of human fallopian tube shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/75088/167506_A_7_7_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuronal cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8005/22394_B_9_5.jpg
Normal Tissue
Figure 3 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8005/22394_A_7_3.jpg
Normal Tissue
Figure 4 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8005/22394_A_7_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8005/22394_A_7_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8005/22394_A_5_6.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8005/22394_A_8_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (ASC TERT1, BJ, BJ hTERT+, fHDF/TERT166, hTERT-RPE1, U-87 MG)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167779-IGFBP6
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WB
Figure 1 Anti-IGFBP6 Antibody (VS3-FY1746) in WB.
The IGFBP6 expression in K562, Hela lysates were detected using the anti-IGFBP6 by western blot assay.
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Specifications
- Immunogen
- Recombinant human IGFBP6 protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human IGFBP6
- Species Reactivity
- Human
- Clone
- R02-6G2
- Applications
- Western Blot
- MW
- The calculated weight of the target protein is approximately 25 kDa, while the observed molecular weight stands at 35 kDa.
- Related Disease
- Insulin-Like Growth Factor I and Exfoliative Ichthyosis
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- Insulin Like Growth Factor Binding Protein 6
- Gene ID
- 3489
- UniProt ID
- P24592
- Cellular Localization
- Secreted
- Post Translation Modifications
- O-linked glycans consist of hexose (probably Gal), N-acetylhexosamine (probably GalNAc) and sialic acid residues. O-glycosylated with core 1 or possibly core 8 glycans. O-glycosylated on one site only in the region AA 143-168 in cerebrospinal fluid.
- Protein Refseq
- XP_047284742.1; XP_054227929.1; NP_002169.1
- Function
- IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Activates the MAPK signaling pathway and induces cell migration.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "IGFBP6"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2257MZ | Recombinant Mouse Anti-Human IGFBP6 Antibody | ELISA, WB | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0273MZ | Chicken Anti-IGFBP6 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1094CQ | Mouse Anti-IGFBP6 Recombinant Antibody (clone 9L21) | Neut, WB | Mouse IgG2 |
| NEUT-1095CQ | Mouse Anti-IGFBP6 Recombinant Antibody (clone CBL081) | Neut, WB | Mouse IgG2 |
| NEUT-1096CQ | Mouse Anti-IGFBP6 Recombinant Antibody (clone CBL576) | Neut | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3447 | Anti-Mouse IGFBP6 Immunohistochemistry Kit | IHC |
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