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IGFBP6

IGFBP6 (Insulin Like Growth Factor Binding Protein 6) is a Protein Coding gene. Diseases associated with IGFBP6 include Insulin-Like Growth Factor I and Exfoliative Ichthyosis. Among its related pathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include insulin-like growth factor binding and insulin-like growth factor II binding. An important paralog of this gene is IGFBP5.
Protein class

Plasma proteins

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Group enriched (Peritubular cells, Fibroblasts, Sertoli cells, Leydig cells, Basal respiratory cells, Smooth muscle cells)

Immune cell specificity

Immune cell enhanced (eosinophil, non-classical monocyte)

Cell line specificity

Cell line enhanced (ASC TERT1, BJ, BJ hTERT+, fHDF/TERT166, hTERT-RPE1, U-87 MG)

Interaction

Interacts (via C-terminal domain) with PHB2.

Molecular function

Growth factor binding

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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