Rabbit Anti-IGHD Recombinant Antibody (clone R53-4T-7)
CAT#: VS3-FY2124
This rabbit recombinant monoclonal antibody exhibits specificity affinity for human IGHD. The antibody owns calculated molecular weight of 48 kDa, and estimated observed molecular weight of 84 kDa. The R53-4T-7 is recommended for dilution with western blot (dilution 1/500-1/1000), immunohistochemistry (dilution 1/100-1/200).
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Neuronal cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12703/34647_B_8_5.jpg
Normal Tissue
Figure 2 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12703/34647_A_8_5.jpg
Normal Tissue
Figure 3 Testis
Leydig cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12703/34647_A_5_6.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12703/34647_A_9_8.jpg
RNA Expression
Figure 5 RNA cell line category: Group enriched (Daudi, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000211898-IGHD
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human IGHD
- Species Reactivity
- Human
- Clone
- R53-4T-7
- Applications
- Western Blot, Immunohistochemistry-Paraffin
- Conjugate
- Unconjugated
- MW
- The calculated weight of the target protein is approximately 48 kDa, while the observed molecular weight stands at 84kDa.
- Related Disease
- Appendix Lymphoma and Mevalonic Aciduria
Product Property
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS (pH 7.4), 150 mM NaCl, 50% glycerol
- Preservative
- 0.02% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry: 1/100-1/200
Target
- Alternative Names
- Immunoglobulin Heavy Constant Delta
- Gene ID
- 3495
- UniProt ID
- P01880
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Ser109, Ser110, Thr113, Thr126, Thr127, Thr131, Thr132, Asn225, Asn316, and Asn367 (NX_P01880 [NX_P01880-1])
Modification sites at PhosphoSitePlus (P01880)
Glycosylation from GlyConnect IGHD_HUMAN (1943, 2968, 2969)
Glycosylation from GlyGen (P01880) 12 sites, 93 N-linked glycans (4 sites), 9 O-linked glycans (8 sites)
- Function
- IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "IGHD"
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|---|---|---|---|
| MOR-1770 | Rabbit Anti-IGHD Recombinant Antibody (clone DS1770AB) | WB, IHC | Rabbit IgG |
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| VS3-XY850 | Mouse Anti-IGHD Recombinant Antibody (clone 607CT8.4.4) | WB | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3455 | Anti-IGHD Immunohistochemistry Kit | IHC |
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