Rabbit Anti-IGHD Recombinant Antibody (clone R53-4T-7) (CAT#: VS3-FY2124)

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human IGHD

• Species Reactivity
• Human

• Clone
• R53-4T-7

• Applications
• Western Blot, Immunohistochemistry-Paraffin

• Conjugate
• Unconjugated

• MW
• The calculated weight of the target protein is approximately 48 kDa, while the observed molecular weight stands at 84kDa.

• Related Disease
• Appendix Lymphoma and Mevalonic Aciduria

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• PBS (pH 7.4), 150 mM NaCl, 50% glycerol

• Preservative
• 0.02% Sodium azide

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000
  Immunohistochemistry: 1/100-1/200

• Alternative Names
• Immunoglobulin Heavy Constant Delta

• Gene ID
• 3495

• UniProt ID
• P01880

• Cellular Localization
• Cell membrane

• Post Translation Modifications
• Glycosylation at Ser109, Ser110, Thr113, Thr126, Thr127, Thr131, Thr132, Asn225, Asn316, and Asn367 (NX_P01880 [NX_P01880-1])
  Modification sites at PhosphoSitePlus (P01880)
  Glycosylation from GlyConnect IGHD_HUMAN (1943, 2968, 2969)
  Glycosylation from GlyGen (P01880) 12 sites, 93 N-linked glycans (4 sites), 9 O-linked glycans (8 sites)

• Function
• IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody

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