Rabbit Anti-IRF4 Recombinant Antibody (clone R04-5G3) (CAT#: VS3-XY3397)
This product is a recombinant rabbit antibody targeting the IRF4 (Interferon regulatory factor 4), which plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. It specifically recognizes and binds to human IRF4. It has been determined using Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation, Flow cytometry, Immunocytochemistry or Immunofluorescence.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2038/16_E10_2_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2038/16_E10_2_selected.jpg
Figure 2 IF staining of human cell line HDLM-2
(Immunofluorescent staining of human cell line HDLM-2 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2698/1962_G12_2_selected.jpg
(Immunofluorescent staining of human cell line HDLM-2 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2698/1962_G12_2_selected.jpg
Figure 3 IF staining of human cell line A431
(Immunofluorescent staining of human cell line A431 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2038/1779_A5_6_red_green.jpg
(Immunofluorescent staining of human cell line A431 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2038/1779_A5_6_red_green.jpg
Figure 4 Colon
(Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2698/7968_A_8_3.jpg
(Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2698/7968_A_8_3.jpg
Figure 5 RNA cell line category: Cell line enhanced (HDLM-2, Karpas-707, RPMI-8226, U-266/70, U-266/84, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000137265-IRF4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000137265-IRF4
Figure 5 RNA cell line category: Cell line enhanced (HDLM-2, Karpas-707, RPMI-8226, U-266/70, U-266/84, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000137265-IRF4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000137265-IRF4
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human IRF4
- Species Reactivity
- Human
- Clone
- R04-5G3
- Applications
- WB, IHC-P, ICC, IF, IP, FC
- Related Disease
- Skin/Hair/Eye Pigmentation, Variation In, 8 and Whipple Disease.
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
IP: 1/20
FC: 1/50-1/100
Target
- Alternative Names
- MUM1; LSIRF; SHEP8; NF-EM5
- Gene ID
- 3662
- UniProt ID
- Q15306
- Long Name
- Interferon regulatory factor 4
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Phosphorylation by ROCK2 regulates IL-17 and IL-21 production. (Q15306-IRF4_HUMAN)
Modification sites at PhosphoSitePlus (Q15306)
Modification sites at neXtProt (NX_Q15306)
Glycosylation from GlyGen (Q15306) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_006715153.1; XP_047274686.1
- Function
- Transcriptional activator.
Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter.
Binds the immunoglobulin lambda light chain enhancer, together with PU.1.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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IgG Antibody Products
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1286z | Mouse Anti-IRF4 Recombinant Antibody (clone 22A4) | ELISA, IHC, WB | Mouse IgG2a, κ |
| MOB-1266CT | Recombinant Mouse anti-Human IRF4 Monoclonal antibody (3G3) | ELISA, IHC-P, WB | |
| VS3-WK180 | Mouse Anti-IRF4 Recombinant Antibody (clone H7-G10) | WB, ELISA | Mouse IgG1 |
| VS3-WK979 | Mouse Anti-IRF4 Recombinant Antibody (VS3-WK979) | IHC | Mouse IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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