Rabbit Anti-IRF4 Recombinant Antibody (clone R04-5G3) (CAT#: VS3-XY3397)
This product is a recombinant rabbit antibody targeting the IRF4 (Interferon regulatory factor 4), which plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. It specifically recognizes and binds to human IRF4. It has been determined using Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation, Flow cytometry, Immunocytochemistry or Immunofluorescence.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2038/16_E10_2_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2038/16_E10_2_selected.jpg
Figure 2 IF staining of human cell line HDLM-2
(Immunofluorescent staining of human cell line HDLM-2 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2698/1962_G12_2_selected.jpg
(Immunofluorescent staining of human cell line HDLM-2 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2698/1962_G12_2_selected.jpg
Figure 3 IF staining of human cell line A431
(Immunofluorescent staining of human cell line A431 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2038/1779_A5_6_red_green.jpg
(Immunofluorescent staining of human cell line A431 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2038/1779_A5_6_red_green.jpg
Figure 4 Colon
(Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2698/7968_A_8_3.jpg
(Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2698/7968_A_8_3.jpg
Figure 5 RNA cell line category: Cell line enhanced (HDLM-2, Karpas-707, RPMI-8226, U-266/70, U-266/84, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000137265-IRF4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000137265-IRF4
Figure 5 RNA cell line category: Cell line enhanced (HDLM-2, Karpas-707, RPMI-8226, U-266/70, U-266/84, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000137265-IRF4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000137265-IRF4
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human IRF4
- Species Reactivity
- Human
- Clone
- R04-5G3
- Applications
- WB, IHC-P, ICC, IF, IP, FC
- Related Disease
- Skin/Hair/Eye Pigmentation, Variation In, 8 and Whipple Disease.
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
IP: 1/20
FC: 1/50-1/100
Target
- Alternative Names
- MUM1; LSIRF; SHEP8; NF-EM5
- Gene ID
- 3662
- UniProt ID
- Q15306
- Long Name
- Interferon regulatory factor 4
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Phosphorylation by ROCK2 regulates IL-17 and IL-21 production. (Q15306-IRF4_HUMAN)
Modification sites at PhosphoSitePlus (Q15306)
Modification sites at neXtProt (NX_Q15306)
Glycosylation from GlyGen (Q15306) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_006715153.1; XP_047274686.1
- Function
- Transcriptional activator.
Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter.
Binds the immunoglobulin lambda light chain enhancer, together with PU.1.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1286z | Mouse Anti-IRF4 Recombinant Antibody (clone 22A4) | ELISA, IHC, WB | Mouse IgG2a, κ |
| MOB-1266CT | Recombinant Mouse anti-Human IRF4 Monoclonal antibody (3G3) | ELISA, IHC-P, WB | |
| VS3-WK180 | Mouse Anti-IRF4 Recombinant Antibody (clone H7-G10) | WB, ELISA | Mouse IgG1 |
| VS3-WK979 | Mouse Anti-IRF4 Recombinant Antibody (VS3-WK979) | IHC | Mouse IgG |
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For Research Use Only. Not For Clinical Use.
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