Mouse Anti-ITGA6 Recombinant Antibody (VS7-0425-WR156) (CAT#: VS7-0425-WR156)

• Immunogen
• Recombinant human ITGA6 (N-terminus) fragment expressed in E. Coli.

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• Human ITGA6

• Species Reactivity
• Human, Mouse, Rat, Bovine, Dog, Pig

• Molecule Class
• Integrin/Cell Adhesion Molecule

• Applications
• WB, IF, ICC

• Conjugate
• Unconjugated

• Related Disease
• Epidermolysis bullosa; Certain types of cancer; Kidney diseases

• Clonality
• Monoclonal

• Purity
• >95% as determined by SDS-PAGE and SEC-HPLC analysis

• Format
• Liquid

• Concentration
• 1 mg/mL

• Buffer
• 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl)

• Preservative
• 0.2% sodium azide

• Storage
• Centrifuge briefly prior to opening vial. Aliquot and store at -20°C for one year. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• Western Blot: 1:1000 - 1:2000
  Immunofluorescence: 1:100 - 1:500

• Alternative Names
• JEB6; CD49f; VLA-6; ITGA6A; ITGA6B

• Gene ID
• 16403

• UniProt ID
• Q61739

• Long Name
• Integrin Subunit Alpha 6

• Cellular Localization
• Cell membrane

• Post Translation Modifications
• Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation.
  Phosphorylation occurs on 'Ser-1103' of isoform alpha-6X1X2A.
  Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand.
  Undergoes PLAU-mediated cleavage at residues Arg-634-635-Arg in a time-dependent manner to produce processed integrin alpha-6 (alpha6p).
  Production of alpha6p enhances prostate cancer cell invasion and migration.
  Palmitoylation by DHHC3 enhances stability and cell surface expression.
  Glycosylation at Asn78, Asn323, Asn223, Asn409, Asn770, Asn787, Asn930, Asn966, and Asn997
  Modification sites at PhosphoSitePlus
  Glycosylation from Gly
  Glycosylation from GlyGen 14 sites, 20 N-linked glycans (4 sites), 1 O-linked glycan (1 site)

• Protein Refseq
• NP_000201

• Function
• protein binding; receptor activity;

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

• 2ND-042CQ
• Rabbit Anti-Mouse IgG (H&L) Antibody

Select a product category from the dropdown menu below to view related products.