Rabbit Anti-ITPR3 Recombinant Antibody (clone 2506W09)
CAT#: VS-0625-FY37
The Rabbit IgG monoclonal antibody, clone 2506W09, specifically targets human ITPR3. Its immunogen is a recombinant fusion protein of human ITPR3, with an epitope mapping to amino acids 323-342. With an approximate antigen size of 32 kDa, it's suitable for Western Blot (1:2000-1:6000) and ELISA (1 µg/mL), offering a reliable tool for ITPR3 research.
Specifications
- Immunogen
- A recombinant fusion protein containing a sequence corresponding to amino acids 1630-1870 of human ITPR3.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Species Reactivity
- Human
- Clone
- 2506W09
- Applications
- Western Blot
- Related Disease
- Charcot-Marie-Tooth Disease, Demyelinating, Type 1J and Type 1 Diabetes Mellitus
Product Property
- Purification
- Purified with Protein A or G affinity chromatography
- Purity
- >90% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS, pH 7.3, 50% glycerol, 0.05% BSA
- Preservative
- 0.05% ProClin 300
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Western Blot: 1:2000-1:6000
ELISA: 1 µg/mL
Optimal dilutions for assays should be determined by the user.
Target
- Alternative Names
- Inositol 1,4,5-Trisphosphate Receptor Type 3
- Gene ID
- 3710
- UniProt ID
- Q14573
- Long Name
- Inositol 1,4,5-Trisphosphate Receptor Type 3
- Sequence Similarities
- Belongs to the InsP3 receptor family.
- Cellular Localization
- Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000250 UniProtKB:Q63269 | ECO:0000255}
Cytoplasmic vesicle, secretory vesicle membrane
- Post Translation Modifications
- Phosphorylated by AKT1 on serine and/or threonine residues.
Glycosylation at Asn2405
Ubiquitination at Lys1589
Modification sites at PhosphoSitePlus
Glycosylation
- Protein Refseq
- XP_011512879.1; XP_016866321.1; XP_047274687.1; XP_047274688.1; XP_047274689.1
- Function
- Inositol 1,4,5-trisphosphate-gated calcium channel that, upon 1D-myo-inositol 1,4,5-trisphosphate binding, transports calcium from the endoplasmic reticulum lumen to cytoplasm, thus releasing the intracellular calcium and therefore participates in cellular calcium ion homeostasis.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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