Rabbit Anti-ITPR3 Recombinant Antibody (clone 2506W09) (CAT#: VS-0625-FY37)

• Immunogen
• A recombinant fusion protein containing a sequence corresponding to amino acids 1630-1870 of human ITPR3.

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Species Reactivity
• Human

• Clone
• 2506W09

• Applications
• Western Blot

• Related Disease
• Charcot-Marie-Tooth Disease, Demyelinating, Type 1J and Type 1 Diabetes Mellitus

• Purification
• Purified with Protein A or G affinity chromatography

• Purity
• >90% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• PBS, pH 7.3, 50% glycerol, 0.05% BSA

• Preservative
• 0.05% ProClin 300

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• Western Blot: 1:2000-1:6000
  ELISA: 1 µg/mL
  Optimal dilutions for assays should be determined by the user.

• Alternative Names
• Inositol 1,4,5-Trisphosphate Receptor Type 3

• Gene ID
• 3710

• UniProt ID
• Q14573

• Long Name
• Inositol 1,4,5-Trisphosphate Receptor Type 3

• Sequence Similarities
• Belongs to the InsP3 receptor family.

• Cellular Localization
• Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000250 UniProtKB:Q63269 | ECO:0000255}
  Cytoplasmic vesicle, secretory vesicle membrane

• Post Translation Modifications
• Phosphorylated by AKT1 on serine and/or threonine residues.
  Glycosylation at Asn2405
  Ubiquitination at Lys1589
  Modification sites at PhosphoSitePlus
  Glycosylation

• Protein Refseq
• XP_011512879.1; XP_016866321.1; XP_047274687.1; XP_047274688.1; XP_047274689.1

• Function
• Inositol 1,4,5-trisphosphate-gated calcium channel that, upon 1D-myo-inositol 1,4,5-trisphosphate binding, transports calcium from the endoplasmic reticulum lumen to cytoplasm, thus releasing the intracellular calcium and therefore participates in cellular calcium ion homeostasis.

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody

• 2ND-057CQ
• Donkey Anti-Rabbit IgG (H&L) Antibody

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody