Rabbit Anti-KDM2A Recombinant Antibody (clone R05-4D6) (CAT#: VS3-FY1715)

• Immunogen
• Synthetic peptide of human FBXL11

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human KDM2A

• Species Reactivity
• Human

• Clone
• R05-4D6

• Applications
• Western Blot, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunofluorescence, Immunoprecipitation

• MW
• The calculated weight of the target protein is approximately 133 kDa, while the observed molecular weight stands at 133 kDa.

• Related Disease
• Duodenum Adenoma and Ossifying Fibromyxoid Tumor

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000
  Immunohistochemistry: 1/50-1/100
  Immunofluorescence: 1/50-1/200
  Immunoprecipitation: 1/20

• Alternative Names
• Lysine Demethylase 2A; F-Box And Leucine-Rich Repeat Protein 11; JmjC Domain-Containing Histone Demethylation Protein 1A; Jumonji C Domain-Containing Histone Demethylase 1A; [Histone-H3]-Lysine-36 Demethylase 1A; Lysine (K)-Specific Demethylase 2A; CXXC-Type Zinc Finger Protein 8; F-Box/LRR-Repeat Protein 11; EC 1.14.11.27; FBXL11; JHDM1A

• Gene ID
• 22992

• UniProt ID
• Q9Y2K7

• Sequence Similarities
• Belongs to the JHDM1 histone demethylase family.

• Cellular Localization
• Chromosome, Nucleus

• Post Translation Modifications
• Mono-ADP-ribosylated at Arg-1020 in response to DNA damage, leading to displacement from chromatin, resulting in increased dimethylation of histone H3 at 'Lys-36'.

• Protein Refseq
• XP_006718543.1; XP_011543163.1; XP_016872880.1; XP_016872881.1; XP_047282579.1

• Function
• Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody

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