Anti-KLK2 Antibody Prodrug, Protease Activated (VS-1025-YC181)
CAT#: VS-1025-YC181
The Anti-KLK2 Antibody Prodrug, Protease Activated (VS-1025-YC181) is an antibody prodrug comprised of a recombinant human antibody targeting human KLK2, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to KLK2 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to KLK2 effectively. KLK2 (Kallikrein-related peptidase 2) is a serine protease whose expression is highly restricted to the prostate gland, and it is a key component of the Prostate-Specific Antigen (PSA) test. Its regulated expression makes it a relevant biomarker for prostate cancer diagnosis and monitoring.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human prostate
Immunohistochemical staining of human prostate shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/764/2093_A_1_5_selected.jpg
Normal Tissue
Figure 2 Prostate
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/764/2093_A_3_5.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (BEWO, NB-4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000167751-KLK2
❮
❯
Specifications
- Host Animal
- Human
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human KLK2
- Target
- KLK2
- Species Reactivity
- Human
- Isotype
- IgG1, kappa
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants.
- Alternative Names
- hK2; hGK-1; KLK2A2
- Gene ID
- 3817
- UniProt ID
- P20151
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "KLK2"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1689z | Mouse Anti-KLK2 Recombinant Antibody (clone 20H6) | ELISA, ICC, IHC-P | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0622CL | Mouse Anti-KLK2 Recombinant Antibody (TAB-0622CL) | FuncS, IF | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0622CL-S(P) | Mouse Anti-KLK2 Recombinant Antibody; scFv Fragment (TAB-0622CL-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0622CL-F(E) | Mouse Anti-KLK2 Recombinant Antibody; Fab Fragment (TAB-0622CL-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2159MZ | Recombinant Mouse Anti-Human KLK2 Antibody (clone 7C8) | ELISA, ICC, IHC-P | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1644CQ | Recombinant Mouse Anti-KLK2 Antibody (CBL629) | WB, IP, Neut | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1961 | Hi-Affi™ Recombinant Rabbit Anti-KLK2 Monoclonal Antibody (DS1961AB) | WB, ICC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0246-CN | Human Anti-KLK2 Recombinant Antibody (HPAB-0246-CN) | ELISA | Humanized IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0246-CN-S(P) | Human Anti-KLK2 Recombinant Antibody; scFv Fragment (HPAB-0246-CN-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0246-CN-F(E) | Human Anti-KLK2 Recombinant Antibody; Fab Fragment (HPAB-0246-CN-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS1-YJ113 | Mouse Anti-KLK2 Recombinant Antibody (clone 6B7) | ELISA, IF, ICC, IHC-P | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS1-YJ114 | Mouse Anti-KLK2 Recombinant Antibody (clone 6B7), HRP | ELISA, IF, ICC, IHC-P | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1197 | Anti-KLK2 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC197 | Recombinant Anti-KLK2 Eliminating Antibody, pH-Sensitive (VS-0625-YC197) | Antigen-Sweeping In Vivo. | Human IgG1 kappa |
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