Anti-KRAS (clone W24V31) Recombinant Antibody Coupled Liposome (VS-1024-FY32)
CAT#: VS-1024-FY32
Lipid nanoparticles that bind to anti-KRAS antibodies show potential in the treatment of human colorectal cancer. These lipid nanoparticles can target the KRAS protein, inhibiting its localization on the cancer cell membrane, thereby affecting the function and growth of cancer cells.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49830/118215_B_9_5.jpg
Normal Tissue
Figure 2 Colon
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49830/118215_A_8_3.jpg
Normal Tissue
Figure 3 Kidney
Cells in tubules
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49830/118215_A_7_5.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49830/118215_A_8_8.jpg
RNA Expression
Figure 5 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000133703-KRAS
❮
❯
More Infomation
Specifications
- Potential Clinical Applications
- Human colon carcinoma, Lung cancer, Ovarian cancer, Pancreatic cancer
Product Composition
- Clone
- W24V31
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This product is a recombinant mouse antibody that was specifically designed to target the K-ras protein. K-ras is a critical oncogene that plays a significant role in cell signaling pathways related to growth and proliferation. Mutations in the K-ras gene are often associated with various types of cancers, making it a vital target for cancer research and therapeutic interventions.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- KRAS
- Introduction
- This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region.
- Alternative Names
- KRAS Proto-Oncogene, GTPase; V-Ki-Ras2 Kirsten Rat Sarcoma 2 Viral Oncogene Homolog; Kirsten Rat Sarcoma Viral Oncogene Homolog; C-Ki-Ras; K-Ras 2; C-K-RAS; KI-RAS; KRAS2; RASK2; V-Ki-Ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog; Kirsten Rat Sarcoma Viral Proto-Oncogene; Cellular Transforming Proto-Oncogene; Cellular C-Ki-Ras2 Proto-Oncogene; Transforming Protein P21; PR310 C-K-Ras Oncogene; C-Kirsten-Ras Protein
- Full Name
- KRAS Proto-Oncogene, GTPase
- Gene ID
- 3845
- UniProt ID
- P01116
- Sequence Similarities
- Belongs to the small GTPase superfamily.
- Cellular Localization
- Cell membrane; Lipid-anchor; Cytoplasmic side; Endomembrane system; Cytoplasm, cytosol
- Post Translation Modifications
- Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs). ( P01116-RASK_HUMAN )
Palmitoylated at Lys-182, Lys-184 and Lys-185 (PubMed:29239724).
Palmitoylation on lysine residues is promoted by palmitoylation at Cys-180 (PubMed:29239724).
Lysine-depalmitoylation by SIRT2 promotes its localization to endomembranes in endocytic pathways
- Protein Refseq
- XP_047284782.1; XP_054227990.1; NP_001356715.1; NP_001356716.1; NP_004976.2
- Function
- Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:20949621).
Plays an important role in the regulation of cell proliferation (PubMed:22711838, 23698361).
Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner.
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-1024-FY32. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "KRAS"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1225z | Mouse Anti-KRAS Recombinant Antibody (clone 23A6) | WB, ELISA, FC, ICC, IF | Mouse IgG2b, κ |
| MOB-1757MZ | Recombinant Mouse Anti-Human KRAS Antibody | FC, IHC-P, WB | Mouse antibody |
| MRO-2154-CN | Rabbit Anti-KRAS Polyclonal Antibody (MRO-2154-CN) | WB, IF, IHC, FC | Rabbit IgG |
| HPAB-N0159-YC | Human Anti-KRAS Recombinant Antibody (HPAB-N0159-YC) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1973 | Hi-Affi™ Recombinant Rabbit Anti-KRAS Monoclonal Antibody (DS1973AB) | WB, ICC, IP | IgG |
| MOR-0031-FY | Rabbit Anti-KRAS Recombinant Antibody (clone AFY0002) | IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0346-YC-VHH | Recombinant Camelid Anti-KRAS Single Domain Antibody (HPAB-0346-YC-VHH) | Cyto, Block, ELISA | Camel VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0159-YC-S(P) | Human Anti-KRAS Recombinant Antibody; scFv Fragment (HPAB-N0159-YC-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0159-YC-F(E) | Human Anti-KRAS Recombinant Antibody; Fab Fragment (HPAB-N0159-YC-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC64 | Rabbit Anti-KRAS Antibody (VS-0924-YC64) - Cancer Stem Cell Marker | IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3825 | Anti-KRAS Immunohistochemistry Kit | IHC |
See Our Custom Production in Action
Popular Products
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: WB, IP, IF, FuncS, FC, Neut, ELISA
Application: Neut, ELISA, FuncS
Application: ELISA, FuncS, IHC, IF, FC, ADCC
Application: WB, ELISA, FuncS, IB, FC, SPR, Apop
Application: Neut, ELISA, FuncS
-2.png)
Application: ELISA
Application: Neut, IHC, Activ, FuncS, IF, ELISA
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
