Recombinant Camelid Anti-KRAS Single Domain Antibody (HPAB-0346-YC-VHH)
CAT#: HPAB-0346-YC-VHH
KRAS is a Kirsten ras oncogene homolog from the mammalian ras gene family. KRAS encodes a protein that is a member of the small GTPase superfamily. The protein is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas, and colorectal carcinoma. Anti-KRAS sdAbs were developed to target wild-type and mutated KRAS (G12D) in order to disrupt its role in malignant cells such as, for example, cells involved in colorectal cancer, pancreatic cancer, biliary tract cancer, lung cancer, leukemias, and other metastatic malignancies.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49830/118215_B_9_5.jpg
Normal Tissue
Figure 2 Colon
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49830/118215_A_8_3.jpg
Normal Tissue
Figure 3 Kidney
Cells in tubules
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49830/118215_A_7_5.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49830/118215_A_8_8.jpg
RNA Expression
Figure 5 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000133703-KRAS
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Specifications
- Host Species
- Camelid
- Derivation
- Ribosome display
- Type
- Camel VHH
- Specificity
- Human KRAS
- Species Reactivity
- Human
- Clone
- HPAB-0346-YC-VHH
- Applications
- Cytotoxicity, Blocking
- Related Disease
- Cancer, Abnormal cellular proliferation
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "KRAS"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1225z | Mouse Anti-KRAS Recombinant Antibody (clone 23A6) | WB, ELISA, FC, ICC, IF | Mouse IgG2b, κ |
| MOB-1757MZ | Recombinant Mouse Anti-Human KRAS Antibody | FC, IHC-P, WB | Mouse antibody |
| MRO-2154-CN | Rabbit Anti-KRAS Polyclonal Antibody (MRO-2154-CN) | WB, IF, IHC, FC | Rabbit IgG |
| HPAB-N0159-YC | Human Anti-KRAS Recombinant Antibody (HPAB-N0159-YC) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1973 | Hi-Affi™ Recombinant Rabbit Anti-KRAS Monoclonal Antibody (DS1973AB) | WB, ICC, IP | IgG |
| MOR-0031-FY | Rabbit Anti-KRAS Recombinant Antibody (clone AFY0002) | IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0159-YC-S(P) | Human Anti-KRAS Recombinant Antibody; scFv Fragment (HPAB-N0159-YC-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0159-YC-F(E) | Human Anti-KRAS Recombinant Antibody; Fab Fragment (HPAB-N0159-YC-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC64 | Rabbit Anti-KRAS Antibody (VS-0924-YC64) - Cancer Stem Cell Marker | IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3825 | Anti-KRAS Immunohistochemistry Kit | IHC |
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