Rabbit Anti-LGMN Recombinant Antibody (clone R06-7G1)
CAT#: VS3-FY1758
The R06-7G1 antibody has been teted by western blot. Legumain antibody detected positive in western blot analysis of legumain in Jurkat, Hela lysates. The recombinant monoclonal antibody demonstrated a greater affinity with human LGMN.
Gene Expression
Tested Data
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line RT4
Immunofluorescent staining of human cell line RT4 shows localization to nucleoplasm & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1426/1766_F1_3_selected.jpg
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WB
Figure 1 Anti-LGMN Antibody (VS3-FY1758) in WB.
The Legumain expression in Jurkat, Hela lysates were detected using the anti-Legumain by western blot assay.
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Specifications
- Immunogen
- Recombinant human Legumain protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human LGMN
- Species Reactivity
- Human
- Clone
- R06-7G1
- Applications
- Western Blot
- MW
- The calculated weight of the target protein is approximately 49 kDa, while the observed molecular weight stands at 56,46,37 kDa.
- Related Disease
- Aneruptive Fever and Cerebral Amyloid Angiopathy, Cst3-Related
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- AEP; LGMN1; PRSC1
- Gene ID
- 5641
- UniProt ID
- Q99538
- Sequence Similarities
- Belongs to the peptidase C13 family.
- Cellular Localization
- Lysosome
- Post Translation Modifications
- Activated by autocatalytic processing at pH 4.
- Protein Refseq
- XP_005267919.1; XP_005267920.1; XP_011535272.1; XP_016876952.1; XP_047287551.1
- Function
- Can also cleave aspartyl bonds slowly, especially under acidic conditions.
Involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.
Also involved in MHC class I antigen presentation in cross-presenting dendritic cells by mediating cleavage and maturation of Perforin-2 (MPEG1), thereby promoting antigen translocation in the cytosol (By similarity).
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "LGMN"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2047 | Hi-Affi™ Recombinant Rabbit Anti-LGMN Monoclonal Antibody (DS2047AB) | WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC672 | AbPlus™ Anti-LGMN Magnetic Beads (VS-0724-YC672) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1242 | Anti-LGMN Immunohistochemistry Kit | IHC | |
| VS-0525-XY4010 | Anti-Human LGMN Immunohistochemistry Kit | IHC |
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