Mouse Anti-LIN28B Recombinant Antibody (VS3-FY2788) (CAT#: VS3-FY2788)
This mouse anti-LIN28B recombinant monoclonal antibody is specifically targeting the human, mouse LIN28B protein, a calculated molecular weight of the protein is about 27.1 kDa. This monoclonal antibody proves valuable in disease research related to Neuroblastoma, Acrocephalopolysyndactyly Type Iii.
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Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HEK 293
(Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm, nucleoli & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/61745/if_selected.jpg
(Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm, nucleoli & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/61745/if_selected.jpg
Figure 2 IHC staining of human placenta
(High expression. RNA expression: 65.4 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/61745/141564_A_3_7_val_selected.jpg
(High expression. RNA expression: 65.4 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/61745/141564_A_3_7_val_selected.jpg
Figure 3 IHC staining of human prostate
(Low expression. RNA expression: 0.0 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/61745/141564_A_2_5_val_selected.jpg
(Low expression. RNA expression: 0.0 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/61745/141564_A_2_5_val_selected.jpg
Figure 4 RNA cell line category: Cell line enhanced (AF22, BEWO, Hep G2, K-562, NTERA-2, SuSa)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000187772-LIN28B
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000187772-LIN28B
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human and Mouse LIN28B
- Species Reactivity
- Human, Mouse
- Applications
- Western Blot
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 27.1 kDa.
- Related Disease
- Neuroblastoma; Acrocephalopolysyndactyly Type Iii
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/2000
Target
- Alternative Names
- CSDD2
- Gene ID
- 389421
- UniProt ID
- Q6ZN17
- Cellular Localization
- Nucleus, Nucleolus, Cytoplasm
- Post Translation Modifications
- Modification sites at PhosphoSitePlus (Q6ZN17)
Modification sites at neXtProt (NX_Q6ZN17)
Glycosylation from GlyGen (Q6ZN17) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_054211391.1
- Function
- Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c.
Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA (PubMed:22118463).
Does not act on pri-miR21.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-0927-CN | Recombinant Mouse Anti-LIN28B Monoclonal Antibody (A2-4-5) | WB, IF, IHC | Mouse IgG2a |
| VS3-QX692 | Mouse Anti-LIN28B Recombinant Antibody (clone A2-4-5) | WB, ICC, IHC | Mouse IgG2a |
| VS3-WK1043 | Mouse Anti-LIN28B Recombinant Antibody (VS3-WK1043) | WB | Mouse IgG1, κ |
| VS3-XY3417 | Rabbit Anti-LIN28B Recombinant Antibody (clone R05-7F1) | WB, ICC, IF, IP, FC | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
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