Rabbit Anti-LRRK2 Recombinant Antibody (clone R05-6E9) (CAT#: VS3-XY3421)
This antibody is a recombinant rabbit antibody targeting the LRRK2 (Leucine rich repeat kinase 2), which regulates neuronal process morphology in the intact central nervous system (CNS). It reacts with human, mouse and rat LRRK2. It has been reported for use in Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation, Immunocytochemistry or Immunofluorescence.
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat LRRK2
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R05-6E9
- Applications
- WB, IHC-P, ICC, IF, IP
- Related Disease
- Parkinson Disease 8, Autosomal Dominant; Hereditary Late-Onset Parkinson Disease
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
IP: 1/20
Target
- Alternative Names
- PARK8; RIPK7; ROCO2; AURA17; DARDARIN
- Gene ID
- 120892
- UniProt ID
- Q5S007
- Long Name
- Leucine rich repeat kinase 2
- Cellular Localization
- Cytoplasmic vesicle, Perikaryon, Golgi apparatus membrane, Cell projection, axon
- Post Translation Modifications
- Ubiquitinated by TRIM1; undergoes 'Lys-48'-linked polyubiquitination leading to proteasomal degradation. (Q5S007-LRRK2_HUMAN)
Modification sites at PhosphoSitePlus (Q5S007)
Modification sites at neXtProt (NX_Q5S007)
Glycosylation from GlyGen (Q5S007) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_011536179.1; XP_005268686.1
- Function
- Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking.
Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation.
Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB35, and RAB43.
Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A.
Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
Rabbit Monoclonal Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-4054z | Mouse Anti-LRRK2 Recombinant Antibody (clone 44H4) | WB, IP, ELISA | Mouse IgG1, κ |
| MRO-2017-CN | Rabbit Anti-LRRK2 Polyclonal Antibody (MRO-2017-CN) | IF, IHC | Rabbit IgG |
| VS3-FY861 | Recombinant Mouse Anti-LRRK2 Antibody (clone 2A2A8) | ELISA, ICC, FC | Mouse IgG1 |
| VS3-FY862 | Recombinant Mouse Anti-LRRK2 Antibody (clone 2A4B12) | ELISA, IHC, FC | Mouse IgG1 |
| VS3-WK2048 | Rabbit Anti-LRRK2 (pS935) Recombinant Antibody (clone R94-3M-6) | WB, ICC, IF | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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