Rabbit Anti-LRRK2 Recombinant Antibody (clone R05-6E9) (CAT#: VS3-XY3421)

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human, Mouse and Rat LRRK2

• Species Reactivity
• Human, Mouse, Rat

• Clone
• R05-6E9

• Applications
• WB, IHC-P, ICC, IF, IP

• Related Disease
• Parkinson Disease 8, Autosomal Dominant; Hereditary Late-Onset Parkinson Disease

• Clonality
• Monoclonal

• Aggregation
• < 5%

• Format
• Liquid

• Buffer
• PBS (pH 7.4), 150 mM NaCl and 50% glycerol

• Preservative
• 0.02% sodium azide

• Storage
• Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• WB: 1/500-1/1000
  IHC: 1/50-1/100
  IF: 1/50-1/200
  IP: 1/20

• Alternative Names
• PARK8; RIPK7; ROCO2; AURA17; DARDARIN

• Gene ID
• 120892

• UniProt ID
• Q5S007

• Long Name
• Leucine rich repeat kinase 2

• Cellular Localization
• Cytoplasmic vesicle, Perikaryon, Golgi apparatus membrane, Cell projection, axon

• Post Translation Modifications
• Ubiquitinated by TRIM1; undergoes 'Lys-48'-linked polyubiquitination leading to proteasomal degradation. (Q5S007-LRRK2_HUMAN)
  Modification sites at PhosphoSitePlus (Q5S007)
  Modification sites at neXtProt (NX_Q5S007)
  Glycosylation from GlyGen (Q5S007) 1 site, 1 O-linked glycan (1 site)

• Protein Refseq
• XP_011536179.1; XP_005268686.1

• Function
• Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking.
  Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation.
  Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB35, and RAB43.
  Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A.
  Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Recommended Dilution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS

Secondary Antibody

• 2RD-A1473-YJ
• Goat Anti-Rabbit IgG-F(ab')2 Secondary antibody

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