Anti-MAP2 (clone W24V189) Recombinant Antibody Coupled Liposome (VS-1024-FY190)
CAT#: VS-1024-FY190
This therapeutic strategy utilizes liposomes conjugated with anti-MAP2 antibodies to target melanoma cells specifically. By enhancing the delivery of cytotoxic agents to MAP2-expressing cells, this approach aims to improve treatment efficacy and minimize systemic side effects. The targeting mechanism facilitates intracellular uptake, leading to increased apoptosis in malignant cells. Overall, it represents a promising avenue for targeted melanoma therapy.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line AF22
Immunofluorescent staining of human cell line AF22 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8273/1895_G7_3_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line SH-SY5Y
Immunofluorescent staining of human cell line SH-SY5Y shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12558/1927_F10_1_selected.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8273/24187_A_7_3.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8273/24187_B_7_5.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (AF22, NTERA-2, SCLC-21H, SH-SY5Y)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000078018-MAP2
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More Infomation
Specifications
- Potential Clinical Applications
- Melanoma
Product Composition
- Clone
- W24V189
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant monoclonal antibody that was derived from mouse origin, specifically engineered to target and bind to microtubule-associated protein 2 (MAP2). MAP2 is a crucial protein involved in maintaining the structure and stability of neuronal microtubules, playing a significant role in neuronal development and synaptic function.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- MAP2
- Introduction
- Microtubule-associated protein 2 (MAP2) is a neuronal phosphoprotein that regulates the structure and stability of microtubules, neuronal morphogenesis, cytoskeleton dynamics and organelle trafficking in axons and dendrites. Phosphorylation of MAP2 modulates its association with the cytoskeleton and is developmentally regulated. Serine 136, threonine 1620 and threonine 1623 of MAP2 are phosphorylated by GSK3 and p44/42 MAP kinases. Phosphorylation at threonine 1620/1623 by GSK3 inhibits MAP2 association with microtubules and microtubule stability.
- Alternative Names
- MAP-2A; MAP2B; MAP2C; MAP2
- Full Name
- Microtubule Associated Protein 2
- Gene ID
- 4133
- UniProt ID
- P11137
- Cellular Localization
- Cell projection, Cytoplasm, Cytoskeleton, Microtubule
- Post Translation Modifications
- Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity).
Isoform 2 is probably phosphorylated by PKA at Ser-323, Ser-354 and Ser-386 and by FYN at Tyr-67. The interaction with KNDC1 enhances MAP2 threonine phosphorylation (By similarity).
- Protein Refseq
- NP_001034627.1; NP_002365.3; NP_114033.2
- Function
- The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
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COA
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|---|---|---|---|
| MOB-1172CT | Recombinant Mouse anti-Rat MAP2 Monoclonal antibody (6G0) | IHC-P, WB | |
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| VS3-CJ67 | Mouse Anti-MAP2 Recombinant Antibody (VS3-CJ67) | WB, ELISA | Mouse IgG |
| VS4-CJ25 | Recombinant Mouse Anti-MAP2 Antibody (VS4-CJ25) | ELISA, IHC | Mouse IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0797MZ | Chicken Anti-MAP2 Polyclonal IgY | ICC, IF, IHC, WB | Chicken antibody |
| BRD-1159MZ | Chicken Anti-Microtubule Associated Protein 2 (MAP2) Polyclonal IgY | ICC | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2130 | Hi-Affi™ Recombinant Rabbit Anti-MAP2 Monoclonal Antibody (DS2130AB) | IHC-P, IP, WB | IgG |
| MOR-0097-FY | Rabbit Anti-MAP2 Recombinant Antibody (clone AFY0068) | ICC, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY161 | CytoStream™ Mouse Anti-MAP2 Recombinant Antibody (VS-0225-XY161) | FC | Mouse IgG1, kappa |
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