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MAP2

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Anti-MAP2 Products

    • Species Reactivity: Chicken, Horse, Human, Mouse, Pig, Rat, Bovine
    • Type: Chicken antibody
    • Application: ICC, IF, IHC, WB
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For Research Use Only. Not For Clinical Use.


This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described.
Protein class

FDA approved drug targets, Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Group enriched (Excitatory neurons, Cone photoreceptor cells, Inhibitory neurons, Oligodendrocyte precursor cells, Rod photoreceptor cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (AF22, NTERA-2, SCLC-21H, SH-SY5Y)

Interaction

Interacts with KNDC1 (via KIND2); the interaction enhances MAP2 phosphorylation and localizes KNDC1 to dendrites. Interacts with DPYSL5 (PubMed:33894126).

Molecular function

Calmodulin-binding

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