Rabbit Anti-MCM5 Recombinant Antibody (VS3-FY2798)
CAT#: VS3-FY2798
This anti-MCM5 antibody is a rabbit recombinant monoclonal antibody that with high affinity for human MCM5 protein. It cross-reacts with rat species. This monoclonal antibody proves valuable in disease research related to Meier-Gorlin Syndrome 8 and Deafness, Autosomal Dominant 70. This monoclonal antibody is suitable for employment in Immunoprecipitation (1/20), Western Blot (1/500-1/1000), Immunohistochemistry (1/50-1/100) and Immunocytochemistry (1/50-1/200).
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/845/1763_B_9_5.jpg
Normal Tissue
Figure 2 Colon
Enterocytes Staining: Low Intensity: Moderate Quantity: <25% Enterocytes - Gradient Gradient: Descending Enterocytes - Goblet cells Staining: Low Intensity: Moderate Quantity: <25% Mucosal lymphoid cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/845/1763_A_7_3.jpg
Normal Tissue
Figure 3 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/845/1763_A_4_6.jpg
Normal Tissue
Figure 4 High expression in bone marrow
Hematopoietic cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/845/1763_B_5_4.jpg
Normal Tissue
Figure 5 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/845/1763_A_7_8.jpg
RNA Expression
Figure 6 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000100297-MCM5
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Rat MCM5
- Species Reactivity
- Human, Rat
- Applications
- Western Blot, Immunohistochemistry, Immunocytochemistry, Immunoprecipitation
- Conjugate
- Unconjugated, FITC
- Related Disease
- Meier-Gorlin Syndrome 8 and Deafness, Autosomal Dominant 70
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Immunoprecipitation: 1/20
Western Blot: 1/500-1/1000
Immunohistochemistry: 1/50-1/100
Immunocytochemistry: 1/50-1/200
Target
- Alternative Names
- Minichromosome Maintenance Complex Component 5; CDC46 Homolog; P1-CDC46; CDC46; MCM5 Minichromosome Maintenance Deficient 5, Cell Division Cycle 46 (S. Cerevisiae); Minichromosome Maintenance Deficient (S. Cerevisiae) 5 (Cell Division Cycle 46)
- Gene ID
- 4174
- UniProt ID
- P33992
- Sequence Similarities
- Belongs to the MCM family.
- Cellular Localization
- Nucleus
Chromosome
- Post Translation Modifications
- Ubiquitination at Lys228, Lys337, Lys387, Lys396, Lys407, Lys471, Lys499, Lys627, and Lys696 (NX_P33992 [NX_P33992-1])
Modification sites at PhosphoSitePlus (P33992)
Glycosylation from GlyGen (P33992) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_047297322.1; XP_054181595.1; XP_054181596.1; NP_006730.2
- Function
- Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells.
Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "MCM5"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2193 | Hi-Affi™ Recombinant Rabbit Anti-MCM5 Monoclonal Antibody (DS2193AB) | FC, ICC, IHC-P, IP, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0043-LS | Mouse Anti-MCM5 Recombinant Antibody (HPAB-0043-LS) | ELISA | Mouse IgG |
| HPAB-0044-LS | Mouse Anti-MCM5 Recombinant Antibody (HPAB-0044-LS) | ELISA | Mouse IgG |
| VS3-WK737 | Mouse Anti-MCM5 Recombinant Antibody (clone MC001) | WB, ELISA | Mouse IgG |
| VS3-WK738 | Mouse Anti-MCM5 Recombinant Antibody (clone MC002) | WB, ELISA | Mouse IgG |
| VS13-YC714 | Rabbit Anti-MCM5 Recombinant Antibody (VS13-YC714) | IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0043-LS-F(E) | Mouse Anti-MCM5 Recombinant Antibody; Fab Fragment (HPAB-0043-LS-F(E)) | ELISA | Mouse Fab |
| HPAB-0044-LS-F(E) | Mouse Anti-MCM5 Recombinant Antibody; Fab Fragment (HPAB-0044-LS-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0043-LS-S(P) | Mouse Anti-MCM5 Recombinant Antibody; scFv Fragment (HPAB-0043-LS-S(P)) | ELISA | Mouse scFv |
| HPAB-0044-LS-S(P) | Mouse Anti-MCM5 Recombinant Antibody; scFv Fragment (HPAB-0044-LS-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1322 | Anti-MCM5 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4310 | Anti-Human MCM5 Immunohistochemistry Kit | IHC |
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