Anti-MEF2C Antibody Prodrug, Protease Activated (VS-1025-YC127)
CAT#: VS-1025-YC127
The Anti-MEF2C Antibody Prodrug, Protease Activated (VS-1025-YC127) is an antibody prodrug comprised of a recombinant human antibody targeting human MEF2C, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to MEF2C protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to MEF2C effectively. MEF2C (Myocyte Enhancer Factor 2C) is a transcription factor that is frequently overexpressed due to gene amplification or translocation in certain leukemias, acting as an oncogene. Its high expression promotes the proliferation and inhibits the differentiation of malignant hematopoietic cells.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line RH-30
Immunofluorescent staining of human cell line RH-30 shows localization to nucleoplasm & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5533/if_selected.jpg
Normal Tissue
Figure 2 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68196/152018_A_8_5.jpg
Normal Tissue
Figure 3 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Peritubular cells Staining: Medium Intensity: Moderate Quantity:>75% Spermatogonia cells Staining: Medium Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68196/152018_A_6_6.jpg
Normal Tissue
Figure 4 Skeletal muscle
Myocytes Staining: High Intensity: Strong Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68196/152018_B_2_6.jpg
Normal Tissue
Figure 5 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68196/152018_A_7_8.jpg
Normal Tissue
Figure 6 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68196/152018_B_9_5.jpg
Normal Tissue
Figure 7 Colon
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Enterocytes - Mucosal lymphoid cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68196/152018_A_7_3.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (Daudi, HEL, Karpas-707, REH, WM-115)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000081189-MEF2C
❮
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Specifications
- Host Animal
- Human
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human MEF2C
- Target
- MEF2C
- Species Reactivity
- Human
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- The antibodies that bind selectively to MEF2C (Myocyte-specific enhancer factor 2C)-also known as MADS box transcription enhancer factor 2, polypeptide C, are used for cardiovascular diseases. MEF2C is one of several biomarkers expressed in committed cells differentiated from stem cells. MEF2C is a transcription factor in the MEF2 family of proteins, which play a role in cardiac morphogenesis, myogenesis and also vascular development.
- Alternative Names
- MEF2C; myocyte enhancer factor 2C; DEL5q14.3; C5DELq14.3; myocyte-specific enhancer factor 2C
- Gene ID
- 4208
- UniProt ID
- Q06413
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "MEF2C"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1921z | Mouse Anti-MEF2C Recombinant Antibody (clone 21G4) | WB, FC, ICC, IF, IHC | Mouse IgG2a |
| VS3-WK130 | Mouse Anti-MEF2C Recombinant Antibody (clone G2-H2) | WB, ELISA | Mouse IgG1 |
| VS3-XY1059 | Mouse Anti-MEF2C Recombinant Antibody (clone 6H2G2) | ELISA, WB, IHC, FC | Mouse IgG1 |
| VS3-XY3427 | Rabbit Anti-MEF2C Recombinant Antibody (clone R07-6W9) | WB, IHC-P | Rabbit IgG |
| VS13-YC721 | Rabbit Anti-MEF2C Recombinant Antibody (VS13-YC721) | WB, IHC-P, IHC-Fr, ICC, IF, ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0760CL | Anti-Human MEF2C Recombinant Antibody (9949CB) | ELISA, WB, IF | |
| TAB-0760CL-S(P) | Anti-Human MEF2C Recombinant Antibody scFv Fragment (9949CB) | ELISA, WB, IF | |
| TAB-0760CL-F(E) | Anti-Human MEF2C Recombinant Antibody Fab Fragment (9949CB) | ELISA, WB, IF |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1329 | Anti-MEF2C Immunohistochemistry Kit | IHC | |
| VS-0525-XY4342 | Anti-Mouse MEF2C Immunohistochemistry Kit | IHC | |
| VS-0525-XY4343 | Anti-Rat MEF2C Immunohistochemistry Kit | IHC | |
| VS-0525-XY4341 | Anti-Human MEF2C Immunohistochemistry Kit | IHC |
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