Mouse Anti-MSH2 Recombinant Antibody (clone 4F10D6)
CAT#: VS7-0425-WR417
This product is a mouse IgG2b antibody that binds to human MSH2. The antibody 4F10D6 recognizes specific amino acid domain of human MSH2 (AA: 442-586). It can be used for FC assay.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line RH-30
Immunofluorescent staining of human cell line RH-30 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/66845/1768_C3_11_cr594bb51d24b1e_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9572/if_selected.jpg
Normal Tissue
Figure 3 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: nuclear Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9572/26473_A_9_8.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9572/26473_A_8_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9572/26473_A_7_5.jpg
RNA Expression
Figure 6 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000095002-MSH2
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Specifications
- Immunogen
- Recombinant human MSH2 (AA: 442-586) fragment expressed in E. Coli.
- Host Species
- Mouse
- Type
- Mouse IgG2b
- Specificity
- Human MSH2
- Species Reactivity
- Human
- Clone
- 4F10D6
- Molecule Class
- Muts Complex
- Applications
- FC
- Conjugate
- Unconjugated
- Related Disease
- Lynch syndrome 1 (LYNCH1); Muir-Torre syndrome (MRTES); Endometrial cancer (ENDMC); Mismatch repair cancer syndrome 2 (MMRCS2); Colorectal cancer (CRC)
Product Property
- Clonality
- Monoclonal
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- 0.05% sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Western Blot: 1:500 - 1:2000
Flow Cytometry: 1:200 - 1:400
Enzyme-linked Immunosorbent Assay: 1:10000
Target
- Alternative Names
- MSH2; HNPCC; MutS Protein Homolog 2; MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli); HMSH2; MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1; MutS (E. Coli) Homolog 2 (Colon Cancer, Nonpolyposis Type 1); DNA Mismatch Repair Protein Msh2; HNP
- Gene ID
- 4436
- UniProt ID
- P43246
- Long Name
- MutS Homolog 2
- Cellular Localization
- Chromosome; Nucleus
- Post Translation Modifications
- Acetylation; Isopeptide bond; Phosphoprotein; Ubl conjugation
- Protein Refseq
- NP_000242.1
- Function
- DNA-binding
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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Reconstitution Buffer
- CAT
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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