Rabbit Anti-NCAPH2 Recombinant Antibody (clone R06-8I5) (CAT#: VS3-FY1786)

• Immunogen
• Synthetic peptide of human NCAPH2

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human NCAPH2

• Species Reactivity
• Human

• Clone
• R06-8I5

• Applications
• Western Blot, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunofluorescence, Immunoprecipitation

• MW
• The calculated weight of the target protein is approximately 68 kDa, while the observed molecular weight stands at 68 kDa.

• Related Disease
• Cox Deficiency, Infantile Mitochondrial Myopathy and Myopia 6

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000
  Immunohistochemistry: 1/50-1/100
  Immunofluorescence: 1/50-1/200
  Immunoprecipitation: 1/20

• Alternative Names
• Non-SMC Condensin II Complex Subunit H2; CAP-H2 Subunit Of The Condensin II Complex; Chromosome-Associated Protein H2; Kleisin Beta; CAPH2; Non-SMC Condensin II Complex, Subunit H2

• Gene ID
• 29781

• UniProt ID
• Q6IBW4

• Sequence Similarities
• Belongs to the CND2 H2 (condensin-2 subunit 2) family.

• Cellular Localization
• Chromosome, Nucleus

• Post Translation Modifications
• Modification sites at PhosphoSitePlus (Q6IBW4)
  Modification sites at neXtProt (NX_Q6IBW4)
  Glycosylation from GlyGen (Q6IBW4) 1 site, 1 O-linked glycan (1 site)

• Protein Refseq
• XP_005261969.1; XP_011528987.1; XP_016884282.1; XP_047297308.1; XP_047297309.1

• Function
• May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity).

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody