Rabbit Anti-NFKBIB Recombinant Antibody (clone R02-3C1)
CAT#: VS3-FY1748
This R02-3C1 recombinant monoclonal antibody is specifically designed to target human NFKBIB. It cross-reacts with mouse. It is suitable for use in a variety of assays, including WB, IHC-P, IP. The specificity of the IKB beta antibody was confirmed by western blot analysis of IKB beta in K562, 3T3, Hela lysates.
Gene Expression
Tested Data
Subcellular Location
Figure 1 IF staining of human cell line A549
Immunofluorescent staining of human cell line A549 shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63734/1139_C10_2_selected.jpg
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WB
Figure 1 Anti-NFKBIB Antibody (VS3-FY1748) in WB.
The IKB beta expression in K562, 3T3, Hela lysates were detected using the anti-IKB beta by western blot assay.
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Specifications
- Immunogen
- Synthetic peptide of human IKB beta
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Mouse NFKBIB
- Species Reactivity
- Human, Mouse
- Clone
- R02-3C1
- Applications
- Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation
- MW
- The calculated weight of the target protein is approximately 38 kDa, while the observed molecular weight stands at 48 kDa.
- Related Disease
- Ectodermal Dysplasia 10A, Hypohidrotic/Hair/Nail Type, Autosomal Dominant
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry: 1/50-1/100
Immunoprecipitation: 1/20
Target
- Alternative Names
- NFKB Inhibitor Beta; Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor, Beta; Thyroid Receptor-Interacting Protein 9; NF-Kappa-B Inhibitor Beta; TR-Interacting Protein 9; I-Kappa-B-Beta; NF-Kappa-BIB
- Gene ID
- 4793
- UniProt ID
- Q15653
- Sequence Similarities
- Belongs to the NF-kappa-B inhibitor family.
- Cellular Localization
- Cytoplasm, Nucleus
- Post Translation Modifications
- Phosphorylated by RPS6KA1; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation.
- Protein Refseq
- NP_001230045.1; NP_002494.2
- Function
- Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "NFKBIB"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-485MZ | Human Anti-NFKBIB Recombinant Antibody (TAB-485MZ) | Cyt, FC, WB | Human IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-485MZ-S(P) | Human Anti-NFKBIB Recombinant Antibody; scFv Fragment (TAB-485MZ-S(P)) | FC, Confocal microscopy, WB, IP | Human scFv |
| TAB-485MZ-F(E) | Human Anti-NFKBIB Recombinant Antibody; Fab Fragment (TAB-485MZ-F(E)) | FC, Confocal microscopy, WB, IP | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0882CT | Recombinant Mouse anti-Human NFKBIB Monoclonal antibody (EML735) | WB | |
| VS3-WK988 | Mouse Anti-NFKBIB Recombinant Antibody (clone 1F3) | IHC-P, IF | Mouse IgG |
| VS3-WK990 | Rabbit Anti-NFKBIB Recombinant Antibody (VS3-WK990) | WB, ICC, IHC, IP | Rabbit IgG |
| VS4-CJ55 | Recombinant Mouse Anti-NFKBIB Antibody (VS4-CJ55) | ELISA, IHC | Mouse IgG |
| VS13-YC802 | Rabbit Anti-NFKBIB Recombinant Antibody (VS13-YC802) | WB, IHC-P, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2436 | Hi-Affi™ Recombinant Rabbit Anti-NFKBIB Monoclonal Antibody (DS2436AB) | ICC, IHC-P, IP, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1227 | AbPlus™ Anti-NFKBIB Magnetic Beads (VS-0724-YC1227) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4823 | Anti-NFKBIB Immunohistochemistry Kit | IHC |
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