Rabbit Anti-NFKBIB Recombinant Antibody (clone R02-3C1) (CAT#: VS3-FY1748)
This R02-3C1 recombinant monoclonal antibody is specifically designed to target human NFKBIB. It cross-reacts with mouse. It is suitable for use in a variety of assays, including WB, IHC-P, IP. The specificity of the IKB beta antibody was confirmed by western blot analysis of IKB beta in K562, 3T3, Hela lysates.
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WB
Figure 1 Anti-NFKBIB Antibody (VS3-FY1748) in WB.
The IKB beta expression in K562, 3T3, Hela lysates were detected using the anti-IKB beta by western blot assay.
Specifications
- Immunogen
- Synthetic peptide of human IKB beta
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Mouse NFKBIB
- Species Reactivity
- Human, Mouse
- Clone
- R02-3C1
- Applications
- Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation
- MW
- The calculated weight of the target protein is approximately 38 kDa, while the observed molecular weight stands at 48 kDa.
- Related Disease
- Ectodermal Dysplasia 10A, Hypohidrotic/Hair/Nail Type, Autosomal Dominant
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry: 1/50-1/100
Immunoprecipitation: 1/20
Target
- Alternative Names
- NFKB Inhibitor Beta; Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor, Beta; Thyroid Receptor-Interacting Protein 9; NF-Kappa-B Inhibitor Beta; TR-Interacting Protein 9; I-Kappa-B-Beta; NF-Kappa-BIB
- Gene ID
- 4793
- UniProt ID
- Q15653
- Sequence Similarities
- Belongs to the NF-kappa-B inhibitor family.
- Cellular Localization
- Cytoplasm, Nucleus
- Post Translation Modifications
- Phosphorylated by RPS6KA1; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation.
- Protein Refseq
- NP_001230045.1; NP_002494.2
- Function
- Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgM Antibody Products
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-485MZ | Human Anti-NFKBIB Recombinant Antibody (TAB-485MZ) | Cyt, FC, WB | Human IgM |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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