Rabbit Anti-NFKBIB Recombinant Antibody (VS13-YC802) (CAT#: VS13-YC802)
The Rabbit Anti-NFKBIB Recombinant Antibody is specific for human and mouse NFKBIB. NFKBIB also encodes an NF-kappa-B inhibitor, trapping NF-kappa-B in the cytoplasm. Phosphorylation leads to its degradation, freeing NF-kappa-B for nuclear translocation and activation. Splice variants provide functional diversity. The anti-NFKBIB antibody can be used for Western blot (1/500-1/1000), Immunohistochemistry (1/50-1/100), Immunoprecipitation (1/20).
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Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line A549
(Immunofluorescent staining of human cell line A549 shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63734/1139_C10_2_selected.jpg
(Immunofluorescent staining of human cell line A549 shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63734/1139_C10_2_selected.jpg
Figure 2 RNA cell line category: Cell line enhanced (HDLM-2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000104825-NFKBIB
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000104825-NFKBIB
Specifications
- Immunogen
- Recombinant human IKB beta.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Mouse NFKBIB
- Species Reactivity
- Human, Mouse
- Applications
- WB, IHC-P, IP
- Conjugate
- NONE
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity Chromatography purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 50 mM Tris-Glycine (pH 7.4) containing 150 mM NaCl, 40% Glycerol and 0.05% BSA.
- Preservative
- 0.01% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500-1/1000
Immunohistochemistry (IHC): 1/50-1/100
Immunoprecipitation (IP): 1/20
Target
- Alternative Names
- NFKB Inhibitor Beta; Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor, Beta; Thyroid Receptor-Interacting Protein 9; NF-Kappa-B Inhibitor Beta; TR-Interacting Protein 9; I-Kappa-B-Beta; NF-Kappa-BIB;
- Gene ID
- 4793
- UniProt ID
- Q15653
- Long Name
- NFKB Inhibitor Beta
- Sequence Similarities
- Belongs to the NF-kappa-B inhibitor family.
- Cellular Localization
- Cytoplasm; Nucleus
- Protein Refseq
- NP_001230045.1; NP_002494.2
- Function
- Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgM Antibody Products
Human Antibody Products
Rabbit Monoclonal Antibody Products
IgG Antibody Products
Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-485MZ | Human Anti-NFKBIB Recombinant Antibody (TAB-485MZ) | Cyt, FC, WB | Human IgM |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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