CytoStream™ Rabbit Anti-NLRP3 Recombinant Antibody (VS13-YC817) (CAT#: VS13-YC817)
The CytoStream™ Rabbit Anti-NLRP3 Recombinant Antibody is specific for human, mouse and rat NLRP3. NLRP3 encodes a pyrin-like protein part of the NALP3 inflammasome, involved in innate immunity and inflammatory responses. Mutations relate to conditions like FCAS and MWS, with splicing variants diversifying its function. The anti-NLRP3 antibody was developed and selected by our CytoStream™ platform and the mAb is recommended for use in flow cytometry staining (1/50-1/100).
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 IHC staining of human tonsil
(Immunohistochemical staining of human tonsil shows moderate cytoplasmic positivity in germinal and non-germinal center cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12878/29164_A_6_8_selected.jpg
(Immunohistochemical staining of human tonsil shows moderate cytoplasmic positivity in germinal and non-germinal center cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12878/29164_A_6_8_selected.jpg
Figure 2 Cerebral cortex
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12878/29164_B_8_5.jpg
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12878/29164_B_8_5.jpg
Figure 3 Colon
(Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12878/29164_A_8_3.jpg
(Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12878/29164_A_8_3.jpg
Figure 4 Testis
(Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12878/29164_A_6_6.jpg
(Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12878/29164_A_6_6.jpg
Figure 5 Bone marrow
(Hematopoietic cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12878/29164_B_5_4.jpg
(Hematopoietic cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12878/29164_B_5_4.jpg
Figure 6 Lymph node
(Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12878/29164_A_8_8.jpg
(Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12878/29164_A_8_8.jpg
Figure 7 RNA cell line category: Cell line enriched (THP-1)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000162711-NLRP3
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000162711-NLRP3
Specifications
- Immunogen
- Recombinant human NLRP3, aa 5-161.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat NLRP3
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, IHC-P, ICC, IF, FC
- Conjugate
- NONE
- Related Disease
- Familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), Chronic infantile neurological cutaneous and articular (CINCA) syndrome, and Neonatal-onset multisystem inflammatory disease (NOMID)
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500-1/1000
Immunocytochemistry (ICC): 1/100-1/500
Immunofluorescence (IF): 1/100-1/500
Immunohistochemistry-paraffin (IHC-P): 1/50-1/400
Flow cytometry (FC): 1/50-1/100
Target
- Alternative Names
- NLR Family Pyrin Domain Containing 3; Cryopyrin; Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 3; Cold-Induced Autoinflammatory Syndrome 1 Protein; PYRIN-Containing APAF1-Like Protein 1; Caterpiller Protein 1.1; C1orf7; CLR1.1; PYPAF1; CIAS1; NALP3; NACHT Domain-, Leucine-Rich Repeat-, And PYD-Containing Protein 3; NACHT, LRR And PYD Domains-Containing Protein 3;
- Gene ID
- 114548
- UniProt ID
- Q96P20
- Long Name
- NLR Family Pyrin Domain Containing 3
- Cellular Localization
- Secreted; Nucleus; Endoplasmic reticulum; Cytoplasm; Inflammasome
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2811z | Mouse Anti-NLRP3 Recombinant Antibody (MOB-2811z) | WB, IHC, IHC-Fr, IHC-P, IP | Mouse IgG1 |
| MRO-1097-CN | Recombinant Rabbit Anti-NLRP3 Monoclonal Antibody (CBACN-403) | WB, IF, IHC, IP, FC | Rabbit IgG |
| VS3-WK1107 | Rabbit Anti-NLRP3 Recombinant Antibody (VS3-WK1107) | WB, ICC, IF, IHC, IP, FC | Rabbit IgG |
| VS3-FY1046 | Recombinant Rabbit Anti-NLRP3 Antibody (clone R07-9E9) | WB | Rabbit IgG |
| VS13-YC816 | Rabbit Anti-NLRP3 Polyclonal Antibody (VS13-YC816) | WB, IHC, IF | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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