Rabbit Anti-NOP10 Recombinant Antibody (clone R05-5C3) (CAT#: VS3-FY2052)

• Immunogen
• Synthetic peptide of human NOP10

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human NOP10

• Species Reactivity
• Human

• Clone
• R05-5C3

• Applications
• Western Blot, Immunohistochemistry-Paraffin

• MW
• The calculated weight of the target protein is approximately 8 kDa, while the observed molecular weight stands at 8 kDa.

• Related Disease
• Dyskeratosis Congenita, Autosomal Recessive 1 and Pulmonary Fibrosis And/Or Bone Marrow Failure Syndrome, Telomere-Related, 9

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% glycerol, 0.05% BSA

• Preservative
• 0.01% Sodium azide

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000
  Immunohistochemistry: 1/50-1/100

• Alternative Names
• NOP10 Ribonucleoprotein; Nucleolar Protein Family A, Member 3 (H/ACA Small Nucleolar RNPs); Nucleolar Protein Family A Member 3; Homolog Of Yeast Nop10p; Nucleolar Protein 10; SnoRNP Protein NOP10; NOLA3

• Gene ID
• 55505

• UniProt ID
• Q9NPE3

• Sequence Similarities
• Belongs to the NOP10 family.

• Cellular Localization
• Nucleus

• Post Translation Modifications
• Modification sites at PhosphoSitePlus (Q9NPE3)
  Modification sites at neXtProt (NX_Q9NPE3)
  Glycosylation from GlyGen (Q9NPE3) 1 site, 1 O-linked glycan (1 site)

• Protein Refseq
• NP_061118.1

• Function
• Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA.
  This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody

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