Mouse Anti-NRCAM Recombinant Antibody (clone 7D8C5) (CAT#: VS7-0425-WR506)

• Immunogen
• Recombinant human NRCAM (AA: 1192-1255) fragment expressed in E. Coli.

• Host Species
• Mouse

• Type
• Mouse IgG1

• Specificity
• Human NRCAM

• Species Reactivity
• Human

• Clone
• 7D8C5

• Molecule Class
• L1 Family Of Immunoglobulin Superfamily (IGSF) Cell Adhesion Molecules (CAMs)

• Applications
• ICC

• Conjugate
• Unconjugated

• Related Disease
• Neurodevelopmental disorder with neuromuscular and skeletal abnormalities (NEDNMS)

• Clonality
• Monoclonal

• Purity
• >95% as determined by SDS-PAGE and SEC-HPLC analysis

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• PBS

• Preservative
• 0.05% sodium azide

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• Western Blot: 1:500 - 1:2000
  Immunocytochemistry: 1:50
  Enzyme-linked Immunosorbent Assay: 1:10000

• Alternative Names
• NEDNMS

• Gene ID
• 4897

• UniProt ID
• Q92823

• Long Name
• Neuronal cell adhesion molecule

• Cellular Localization
• Cell membrane; Cell projection; Membrane; Secreted

• Post Translation Modifications
• Disulfide bond; Glycoprotein; Phosphoprotein

• Protein Refseq
• NP_001032209.1

• Function
• Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.

Isotype Control

• MOB-065CQ
• Mouse IgG1 Isotype Control Antibody

Secondary Antibody

• 2RD-A1562-YJ
• Rabbit Anti-Mouse IgG1 Secondary antibody (Clone RM106)

Reconstitution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS

Recommended Dilution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS

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