Rabbit Anti-NRCAM Recombinant Antibody (clone R08-8J3) (CAT#: VS3-XY3455)
This is a recombinant rabbit antibody that specifically recognizes human NRCAM (Neuronal cell adhesion molecule), which plays a role in neurite outgrowth in response to contactin binding. NRCAM also plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. The antibody has been reported for use in Western Blot and Immunoprecipitation.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line EFO-21
(Immunofluorescent staining of human cell line EFO-21 shows localization to nucleoplasm, plasma membrane & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12606/1830_A1_61_selected.jpg
(Immunofluorescent staining of human cell line EFO-21 shows localization to nucleoplasm, plasma membrane & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12606/1830_A1_61_selected.jpg
Figure 2 IHC staining of human cerebral cortex
(Immunohistochemical staining of human cerebral cortex shows distinct positivity in neuropil.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12606/ihc_selected.jpg
(Immunohistochemical staining of human cerebral cortex shows distinct positivity in neuropil.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12606/ihc_selected.jpg
Figure 3 Cerebral cortex
(Glial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12606/57354_B_9_5.jpg
(Glial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12606/57354_B_9_5.jpg
Figure 4 Colon
(Glandular cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12606/57354_A_9_3.jpg
(Glandular cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12606/57354_A_9_3.jpg
Figure 5 Testis
(Leydig cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12606/57354_A_4_6.jpg
(Leydig cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12606/57354_A_4_6.jpg
Figure 6 Lymph node
(Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12606/57354_A_9_8.jpg
(Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12606/57354_A_9_8.jpg
Figure 7 RNA cell line category: Cell line enhanced (A549, AF22, EFO-21, HMC-1, SH-SY5Y)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000091129-NRCAM
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000091129-NRCAM
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human NRCAM
- Species Reactivity
- Human
- Clone
- R08-8J3
- Applications
- WB, IP
- Related Disease
- Non-Specific Syndromic Intellectual Disability
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IP: 1/20
Target
- Alternative Names
- NEDNMS
- Gene ID
- 4897
- UniProt ID
- Q92823
- Long Name
- Neuronal cell adhesion molecule
- Cellular Localization
- Cell membrane, Cell projection
- Post Translation Modifications
- Glycosylation at Asn83, Asn223, Asn245, Asn251, Asn276, Asn314, Asn433, Asn507, Asn619, Asn716, Asn802, Asn858, Asn993, Asn1009, Asn1019, Asn1072, Asn1083, and Asn1115 (NX_Q92823 [NX_Q92823-1])
Modification sites at PhosphoSitePlus (Q92823)
Glycosylation from GlyConnect NRCAM_HUMAN (821)
Glycosylation from GlyGen (Q92823) 22 sites, 20 N-linked glycans (9 sites), 1 O-linked glycan (1 site)
- Protein Refseq
- XP_006716075.1
- Function
- Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system.
Plays a role in neurite outgrowth in response to contactin binding.
Plays a role in mediating cell-cell contacts between Schwann cells and axons.
Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1456CT | Recombinant Mouse anti-Human NRCAM Monoclonal antibody (NN0506-9F36) | WB | |
| MRO-2084-CN | Rabbit Anti-NRCAM Polyclonal Antibody (MRO-2084-CN) | WB, IF, IHC | Rabbit IgG |
| VS3-XY1183 | Mouse Anti-NRCAM Recombinant Antibody (clone 1F3) | ELISA, WB | Mouse IgG1 |
| VS13-YC843 | Rabbit Anti-NRCAM Recombinant Antibody (VS13-YC843) | WB, IHC-P, IHC-Fr, ICC, IF, ELISA | Rabbit IgG |
| VS7-0425-WR506 | Mouse Anti-NRCAM Recombinant Antibody (clone 7D8C5) | ICC | Mouse IgG1 |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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