Rabbit Anti-NRG3 Recombinant Antibody (clone R02-9E5)
CAT#: VS3-FY1802
This R02-9E5 recombinant monoclonal antibody exhibits specific binding to human NRG3. It cross-reacts with rat. The NRG3 antibody has been teted positive by western blot analysis of NRG3 in K562, rat brain lysates.
Gene Expression
Tested Data
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75789/1672_E7_32_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (HEK93, SK-MEL-30, U-2 OS)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000185737-NRG3
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WB
Figure 1 Anti-NRG3 Antibody (VS3-FY1802) in WB.
The NRG3 expression in K562, rat Brain lysates were detected using the anti-NRG3 by western blot assay.
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Specifications
- Immunogen
- Synthetic peptide of human NRG3
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Rat NRG3
- Species Reactivity
- Human, Rat
- Clone
- R02-9E5
- Applications
- Western Blot
- MW
- The calculated weight of the target protein is approximately 78 kDa, while the observed molecular weight stands at 55 kDa.
- Related Disease
- Hirschsprung Disease 1 and Schizoaffective Disorder
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- Neuregulin 3; Pro-NRG3; Pro-Neuregulin-3, Membrane-Bound Isoform; Neuregulin-3-Like Polypeptide; Neuregulin 3 Variant 10; Neuregulin 3 Variant 11; Neuregulin 3 Variant 12; Neuregulin 3 Variant 13; Neuregulin 3 Variant 14; Neuregulin 3 Variant 1
- Gene ID
- 10718
- UniProt ID
- P56975
- Sequence Similarities
- Belongs to the neuregulin family.
- Cellular Localization
- Cell membrane, Membrane, Secreted
- Post Translation Modifications
- Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form. (P56975-NRG3_HUMAN)
Extensive glycosylation precedes the proteolytic cleavage ().
Isoform 3 is glycosylated.
(P56975-NRG3_HUMAN)
Glycosylation at Thr276, Thr277, Thr278, Ser280, and Thr281 (NX_P56975 [NX_P56975-1])
Modification sites at PhosphoSitePlus (P56975)
Glycosylation from GlyGen (P56975) 6 sites, 1 O-linked glycan (6 sites)
- Protein Refseq
- XP_011537474.1; XP_011537475.1; XP_011537477.1; XP_011537480.1; XP_016871062.1
- Function
- Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.
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Related Signaling Pathways
ErbB Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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- Product Name
Secondary Antibody
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- Product Name
See other products for "NRG3"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2500 | Hi-Affi™ Recombinant Rabbit Anti-NRG3 Monoclonal Antibody (DS2500AB) | WB, FC | IgG |
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