Rabbit Anti-NRG3 Recombinant Antibody (clone R02-9E5) (CAT#: VS3-FY1802)

• Immunogen
• Synthetic peptide of human NRG3

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human and Rat NRG3

• Species Reactivity
• Human, Rat

• Clone
• R02-9E5

• Applications
• Western Blot

• MW
• The calculated weight of the target protein is approximately 78 kDa, while the observed molecular weight stands at 55 kDa.

• Related Disease
• Hirschsprung Disease 1 and Schizoaffective Disorder

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000

• Alternative Names
• Neuregulin 3; Pro-NRG3; Pro-Neuregulin-3, Membrane-Bound Isoform; Neuregulin-3-Like Polypeptide; Neuregulin 3 Variant 10; Neuregulin 3 Variant 11; Neuregulin 3 Variant 12; Neuregulin 3 Variant 13; Neuregulin 3 Variant 14; Neuregulin 3 Variant 1

• Gene ID
• 10718

• UniProt ID
• P56975

• Sequence Similarities
• Belongs to the neuregulin family.

• Cellular Localization
• Cell membrane, Membrane, Secreted

• Post Translation Modifications
• Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form. (P56975-NRG3_HUMAN)
  Extensive glycosylation precedes the proteolytic cleavage ().
  Isoform 3 is glycosylated.
  (P56975-NRG3_HUMAN)
  Glycosylation at Thr276, Thr277, Thr278, Ser280, and Thr281 (NX_P56975 [NX_P56975-1])
  Modification sites at PhosphoSitePlus (P56975)
  Glycosylation from GlyGen (P56975) 6 sites, 1 O-linked glycan (6 sites)

• Protein Refseq
• XP_011537474.1; XP_011537475.1; XP_011537477.1; XP_011537480.1; XP_016871062.1

• Function
• Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody

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