Mouse Anti-NUP98 Recombinant Antibody (VS3-FY2826)
CAT#: VS3-FY2826
This anti-NUP98 antibody is a mouse recombinant monoclonal antibody that has been specifically designed to target the human, monkey NUP98 protein, a calculated molecular weight of the protein is about 197.5 kDa. This monoclonal antibody proves valuable in disease research related to Acute Megakaryoblastic Leukemia Without Down Syndrome and Childhood Acute Myeloid Leukemia.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110713-NUP98
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human and Monkey NUP98
- Species Reactivity
- Human, Monkey
- Applications
- Western Blot, Immunocytochemistry, Flow cytometry, ELISA
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 197.5 kDa.
- Related Disease
- Acute Megakaryoblastic Leukemia Without Down Syndrome and Childhood Acute Myeloid Leukemia
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/2000
Immunocytochemistry: 1/50-1/200
Flow cytometry: 1/50-1/200
ELISA: 1/1000-1/10000
Target
- Alternative Names
- Nucleoporin 98; Nucleoporin 98kDa; Nuclear Pore Complex Protein Nup98-Nup96; GLFG-Repeat Containing Nucleoporin; Nuclear Pore Complex Protein Nup98; NUP98/PHF23 Fusion 2 Protein; Nucleoporin 98kD
- Gene ID
- 4928
- UniProt ID
- P52948
- Sequence Similarities
- Belongs to the nucleoporin GLFG family.
- Cellular Localization
- Nucleus membrane
Peripheral membrane protein
Nucleoplasmic side
Nucleus, nuclear pore complex
Nucleus, nucleoplasm
- Post Translation Modifications
- Isoform 1 to isoform 4 are autoproteolytically cleaved to yield Nup98 and Nup96 or Nup98 only, respectively (PubMed:10087256, 20407419, 12191480, 18287282).
Cleaved Nup98 is necessary for the targeting of Nup98 to the nuclear pore and the interaction with Nup96 (PubMed:20407419, 12191480).
(P52948-NUP98_HUMAN)
Proteolytically degraded after poliovirus (PV) infection; degradation is partial and NCP- and TPR-binding domains withstand degradation. (P52948-NUP98_HUMAN)
Glycosylation at Asn606 (NX_P52948 [NX_P52948-1])
Ubiquitination at Lys193, Lys534, Lys572, Lys603, Lys639, Lys757, Lys1019, Lys1040, Lys1052, Lys1222, Lys1341, Lys1405, Lys1601, Lys1608, Lys1668, Lys1722, and Lys1739 (NX_P52948 [NX_P52948-1])
Modification sites at PhosphoSitePlus (P52948)
Glycosylation from GlyConnect NUP98_HUMAN (1578, 2900)
Glycosylation from GlyGen (P52948) 107 sites, 1 N-linked glycan (1 site), 2 O-linked glycans (106 sites)
- Protein Refseq
- NP_001352055.1; NP_001352056.1; NP_001352057.1; NP_001352058.1
- Function
- Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.
NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660).
May anchor NUP153 and TPR to the NPC.
In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134).
Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). NUP98_HUMAN,P52948
(Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133).
Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "NUP98"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2810z | Mouse Anti-NUP98 Recombinant Antibody (clone 32A9) | WB, IP | Mouse IgG1 |
| ZG-0323C | Mouse Anti-NUP98 Recombinant Antibody (ZG-0323C) | WB | Mouse IgG |
| ZG-0324C | Mouse Anti-NUP98 Recombinant Antibody (ZG-0324C) | WB | Mouse IgG |
| VS7-0425-WR516 | Mouse Anti-NUP98 Recombinant Antibody (clone 2F5H8) | WB, FC | Mouse IgG1 |
| VS7-0425-WR517 | Mouse Anti-NUP98 Recombinant Antibody (clone 3G8C7) | WB, ICC, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PNBL-025 | Recombinant Anti-X. tropicalis Nup98 VHH Single Domain Antibody (PNBL-025) | IF | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2528 | Hi-Affi™ Recombinant Rabbit Anti-NUP98 Monoclonal Antibody (DS2528AB) | WB, IHC, ICC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY352 | Rabbit Anti-NHP NUP98 Recombinant Antibody (VS-1024-XY352) | WB, IF, IP | Rabbit IgG |
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